Flexispot Desk Jobs in Usa

1,154 positions found — Page 48

Intellectual Property Partner or Group (Patents, Litigation, Transactions, Life Sciences & Technology Attorneys) for Fast-Growing AmLaw Firm
Salary not disclosed

Intellectual Property Partners / Groups

Patents • IP Litigation • Technology Transactions • Life Sciences • Software

Fast-Growing AmLaw Firm | Nationwide Platform

We are representing a fast-growing AmLaw firm actively building a national intellectual property platform across patent prosecution, IP litigation, life sciences, and technology transactions. The firm is making significant strategic investments in lateral partners and groups who want a scalable platform, stronger economics, and real institutional support for growing sophisticated IP practices.

This is a growth-driven opportunity for partners who want more than just overhead — it is built for IP rainmakers who want cross-selling, premium clients, and a firm that actively invests in their success.

The Platform

The firm represents technology companies, life sciences innovators, venture-backed startups, and Fortune-level enterprises across the full spectrum of IP and technology matters. The IP practice integrates seamlessly with corporate, M&A, private equity, regulatory, and litigation teams, allowing partners to expand wallet share and capture larger, more complex engagements.

The platform supports matters including:

  • Patent prosecution & portfolio management
  • IP litigation (patents, trade secrets, trademarks, copyright)
  • Technology licensing, SaaS, and data transactions
  • IP due diligence for M&A, financings, and investments
  • Life sciences, biotech, pharma, and med-tech IP
  • Cross-border and international IP strategy

Who They’re Looking For

The firm is seeking partners — and partner groups — with:

  • A portable book of business
  • Practices in patents, IP litigation, life sciences, technology, or IP transactions
  • Interest in a platform that delivers real growth, not just a desk and a logo

Portable Books typically start in the at $750K, with flexibility based on synergies, trajectory, and expansion potential.

Why Partners Make This Move

This firm offers:

  • AmLaw-level sophistication with entrepreneurial economics
  • National footprint with flexible office alignment
  • True cross-selling across corporate, PE, litigation, and regulatory
  • Real marketing and business-development infrastructure
  • Leadership opportunities to help shape the IP platform

Partners join because they want more leverage, more referrals, and more upside — without the bureaucracy .

Explore Confidentially

All conversations are handled in strict confidence.

If you are exploring a platform that offers better economics, institutional clients, and a serious commitment to IP growth, we welcome a discreet discussion.

Not Specified
Intellectual Property Partner / Group (Patents, Litigation, Transactions, Life Sciences & Technology Attorneys) for Fast-Growing AmLaw Firm
🏢 Platinum Legal Search Group, LLC
Salary not disclosed
New York, NY 2 days ago

Intellectual Property Partners / Groups

Patents • IP Litigation • Technology Transactions • Life Sciences • Software

Fast-Growing AmLaw Firm | Nationwide Platform

We are representing a fast-growing AmLaw firm actively building a national intellectual property platform across patent prosecution, IP litigation, life sciences, and technology transactions. The firm is making significant strategic investments in lateral partners and groups who want a scalable platform, stronger economics, and real institutional support for growing sophisticated IP practices.

This is a growth-driven opportunity for partners who want more than just overhead — it is built for IP rainmakers who want cross-selling, premium clients, and a firm that actively invests in their success.

The Platform

The firm represents technology companies, life sciences innovators, venture-backed startups, and Fortune-level enterprises across the full spectrum of IP and technology matters. The IP practice integrates seamlessly with corporate, M&A, private equity, regulatory, and litigation teams, allowing partners to expand wallet share and capture larger, more complex engagements.

The platform supports matters including:

  • Patent prosecution & portfolio management
  • IP litigation (patents, trade secrets, trademarks, copyright)
  • Technology licensing, SaaS, and data transactions
  • IP due diligence for M&A, financings, and investments
  • Life sciences, biotech, pharma, and med-tech IP
  • Cross-border and international IP strategy

Who They’re Looking For

The firm is seeking partners — and partner groups — with:

  • A portable book of business
  • Practices in patents, IP litigation, life sciences, technology, or IP transactions
  • Interest in a platform that delivers real growth, not just a desk and a logo

Portable Books typically start in the at $750K, with flexibility based on synergies, trajectory, and expansion potential.

Why Partners Make This Move

This firm offers:

  • AmLaw-level sophistication with entrepreneurial economics
  • National footprint with flexible office alignment
  • True cross-selling across corporate, PE, litigation, and regulatory
  • Real marketing and business-development infrastructure
  • Leadership opportunities to help shape the IP platform

Partners join because they want more leverage, more referrals, and more upside — without the bureaucracy .

Explore Confidentially

All conversations are handled in strict confidence.

If you are exploring a platform that offers better economics, institutional clients, and a serious commitment to IP growth, we welcome a discreet discussion.

Not Specified
School Custodial Cleaner
Salary not disclosed
Fairbanks, Alaska 2 days ago

Pay rate: $16.00-$17.00/hr

Thepaylisted is the hourly range or the hourlyratefor this position. A specific offer will vary based on applicantsexperience, skills, abilities, geographic location,and alignment with market data.

We are looking for a reliable and experienced School Custodian to perform general cleaning duties in designated areas at a K-12 school, college or university campus environment.

Benefit Information: ABM offers a comprehensive benefits package. For information about ABMs benefits, visit ABM Employee Benefits | Front Line Team Members

A good job for someone just entering the workforce or returning to the workforce with limited experience and education. ABM is a military and veteran friendly employer, veterans and candidates with military experience encouraged to apply. Military Occupational Specialty Code: 92S, 92Y, LS, 3051, 3F1X1

Clean and maintain assigned area, which may include classrooms, hallways, restrooms, locker rooms, office, and stairways
Sweep, remove debris, clean spills, and mop floors in designated areas
Regularly check trash receptacles, emptying as needed, in all designated areas
Follow procedures for the use of chemical cleaners and power equipment in order to prevent damage to floors and fixtures
Notify lead cleaner or manager concerning the need for minor or major repairs or additions to building operating systems
Establish and maintain effective communication and working relationships with clients, co-workers, shift coordinators, supervisors, managers, etc.
Collect, consolidate, and separate recycling into proper receptacles
Clean and dust desks, chairs, tables furniture, fixtures, doors, sills, floors, ceiling, and walls Polish hard surfaces, e.g. woodwork, stainless steel surfaces
Wipe and clean tabletops, chairs, and equipment in food areas
Move cabinets, boxes, furniture, crates and equipment to clean areas, either manually or by using hand trucks
Clean interior partition glass, windows, glass partitions, and mirrors using soapy water or other cleaners, sponges, and squeegees
Sweep walks, rake leaves, cut grass, remove snow or perform other incidental seasonal tasks
Maintain the cleanliness of restrooms (clean and polish as needed)
Comply with all safety, security, compliance, and quality standards and procedures established by the Company, Clients, and regulatory authorities

Basic Qualifications:
Must be 18 years of age or older
No experience required and on the job training provided.
No high school diploma, GED or college degree required.

Preferred Qualifications:
Prior customer service experience
One (1) year of prior similar work experience.

About Us


ABM (NYSE: ABM) is one of the worlds largest providers of facility services and solutions. A driving force for a cleaner, healthier, and more sustainable world, ABM provides essential services and forward-looking performance solutions that improve the spaces and places that matter most. From curbside to rooftop, ABMs comprehensive services include janitorial, engineering, parking, electrical and lighting, energy and electric vehicle charging infrastructure, HVAC and mechanical, landscape and turf, and mission critical solutions. ABM serves a wide range of industries from commercial office buildings to universities, airports, hospitals, data centers, manufacturing plants and distribution centers, entertainment venues and more. Founded in 1909, ABM serves over 20,000 clients, with annualized revenue approaching $8 billion and more than 100,000 team members in 350+ offices throughout the United States, United Kingdom, Republic of Ireland, and other international locations. For more information, visit is proud to be an Equal Opportunity Employer qualified applicants without regard race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran or any other protected factor under federal, state, or local law. ABM is committed to working with and providing reasonable accommodation to individuals with disabilities. If you have a disability and need assistance in completing the employment application, please call 888-328-8606. We will provide you with assistance and make a determination on your request for reasonable accommodation on a case-by-case basis.
ABM participates in the U.S. Department of Homeland Security E-Verify program. E-Verify is an internet-based system used to electronically confirm employment eligibility.
ABM is a military-friendly company proudly employing thousands of men and women who have served in the U.S. military. With ABM, youll have access to a world-class training program and ample opportunities to use the skills you developed while serving our country. Whether youre looking for a frontline or professional position, you can find post-military career opportunities across ABM.
ABM directs all applicants to apply at ABM does not accept unsolicited resumes.

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Job Industries

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Not Specified
Litigation Secretary
✦ New
🏢 LHH
Salary not disclosed
Los Angeles, CA 1 day ago

Floater Litigation Secretary


Location: Downtown Los Angeles, CA

Salary: $90,000 – $105,000 per year along with Paid Time Off, Paid Sick Time and Holidays, Healthcare, Dental and Vision

Job Type: Full-Time, Direct Hire, Onsite


LHH is working with a well‑established national law firm seeking an experienced Floater Litigation Secretary with a strong background supporting Labor & Employment matters for their Downtown Los Angeles office. This role will provide support across multiple attorneys in their Employment Litigation practice group, requiring someone adaptable, detail‑oriented, and highly proficient in litigation procedures. Prior experience in Class Action, PAGA, and Wage & Hour matters, is strongly preferred.


Responsibilities

  • Provide litigation secretarial support across various desks and attorney teams as needed
  • Prepare, format, and revise legal documents including pleadings, discovery, motions, and correspondence
  • Handle federal and state court filings, including e‑filing and knowledge of applicable court rules
  • Maintain and update attorney calendars, deadlines, hearings, and case‑related schedules
  • Coordinate and schedule depositions, meetings, mediations, and conference calls
  • Assist with document management, including organizing files, compiling exhibits, and maintaining case records
  • Serve as a professional point of contact for clients, court personnel, and opposing counsel
  • Support Labor & Employment matters, including drafting and preparing materials related to Class Action, PAGA, and Wage & Hour filings
  • Assist with time entry, billing support, and administrative tasks as needed


Qualifications

  • Minimum 3+ years of litigation secretary experience, preferably within Labor & Employment
  • Strong familiarity with federal and state court filing procedures, including e‑filing
  • Experience supporting Class Action, PAGA, and/or Wage & Hour cases strongly preferred
  • Highly proficient in Microsoft Office Suite and legal document management systems
  • Ability to adapt quickly while supporting multiple attorneys with varying needs
  • Strong time management, organizational skills, and attention to detail
  • Excellent written and verbal communication skills
  • Ability to manage shifting priorities in a fast‑paced environment
  • Team‑oriented with a proactive, professional approach


Equal Opportunity Employer/Veterans/Disabled


To read our Candidate Privacy Information Statement, which explains how we will use your information, please navigate to Company will consider qualified applicants with arrest and conviction records in accordance with federal, state, and local laws and/or security clearance requirements, including, as applicable:

  • The California Fair Chance Act
  • Los Angeles City Fair Chance Ordinance
  • Los Angeles County Fair Chance Ordinance for Employers
  • San Francisco Fair Chance Ordinance
Not Specified
Construction Defense Attorney
✦ New
Salary not disclosed

Build Your Career in the Palmetto State: Construction Defect & Insurance Defense Attorney

Does the thought of unravelling complex project blueprints excite you? Do you enjoy the chess match of risk transfer and contractual indemnity? A premier South Carolina law firm is seeking a sharp, driven Construction Defect Attorney to join its growing team.

While the primary hub is in vibrant Columbia, SC, the firm remains open to talent in other major South Carolina markets. This isn't just another desk job; it is a chance to defend general contractors and lead high-stakes insurance defense litigation.


What You’ll Do

This firm trusts its attorneys. You won’t just be "handling" files—you will be the architect of your cases.

  • Lead the Charge: Manage construction defect and insurance defense matters from inception through resolution.
  • Own the Discovery: Take and defend depositions of subcontractors, fact witnesses, and corporate reps.
  • Solve the Puzzle: Synthesize complex project documents like prime contracts, RFIs, and change orders to find the winning edge.
  • Master the Strategy: Navigate multi-party litigation, focusing on equitable indemnity frameworks and trade-based allocation.
  • Collaborate: Work closely with engineering and damages experts to build a rock-solid defense.
  • Advocate: Draft mediation briefs and lead settlement negotiations with a focus on favorable outcomes for the client.


What Makes You the Ideal Candidate?

The firm looks for a mix of technical skill and "big picture" thinking.

  • Experience: You have a background in defending general contractors and upstream parties.
  • Technical Knowledge: You understand the nuances of additional insured tenders and risk transfer.
  • Independence: You can file substantive pleadings and motions with minimal oversight.
  • Communication: You write clear, professional reports for insurance carriers and keep all stakeholders informed.
  • Leadership: You enjoy mentoring junior staff and contributing to a collaborative team culture.


Why This Opportunity?

Our client values efficiency and sound judgment over micromanagement. They offer a professional environment where your issue-spotting skills directly influence the firm's strategy. Furthermore, this role provides:

  1. Direct Carrier Interaction: Build your reputation with major insurance carriers.
  2. Strategic Autonomy: Manage your own budget and case handling strategy.
  3. Growth Potential: Gain exposure to diverse cases across the state of South Carolina.


How to Apply

If you are ready to trade the repetitive "big law" grind for a dynamic role in construction law, we want to hear from you.

Ready to start the conversation? Submit your resume and a brief cover letter highlighting your experience with general contractor defense.

Our agency is an equal opportunity recruiter. All inquiries are kept strictly confidential.

Not Specified
International Import/Export Logistics Representative
✦ New
🏢 Belcan
Salary not disclosed
Pittsburgh, PA 1 day ago

Job Title: International Import/Export Logistics Representative

Pay Rate: $25/hr. (All Inclusive & No Benefits)

Location: Pittsburgh, PA, 15205

This is a 1-year fixed-term contract position. The position may be extended or converted based on business need and performance.


Description:

This is a temporary position responsible for managing import and export operations within Client's International Logistics function. The role is designed for a professional with approximately one year of hands-on international logistics or trade compliance experience.


Major Tasks & Responsibilities:

  • Import & Export Operations - Execute and support import and export transactions across all regions, including off-system exports and off-system imports, in accordance with CIMP and CEMP policies.
  • Coverage Support - Provide desk coverage for team members during vacations and absences, as well as support ongoing project work as needed.
  • 3PL & Broker Management - Manage and coordinate activities with BDP International and other third-party logistics providers as they relate to import and export shipments.


Skills/Qualifications of the Candidate

Education: BS/BA degree in Supply Chain, Logistics, International Business, or a related field preferred; or equivalent combination of education and work experience.


Experience:

  • Minimum 1 year of professional experience in international logistics, import/export operations, or international trade compliance (internship experience does not meet this requirement for this role)
  • Demonstrated working knowledge of import and export compliance execution, monitoring, and operational self-assessments
  • Familiarity with international logistics environments and multi-region trade operations
  • Experience with or exposure to drafting and implementing standard operating procedures (SOPs)


Skills & Competencies:

  • Strong attention to detail with a high degree of accuracy; ability to identify data inconsistencies
  • Effective interpersonal and communication skills; ability to engage stakeholders at all levels
  • Analytical mindset with basic change management and training capabilities
  • Sensitivity to compliance requirements and supply chain risk
  • SAP experience preferred
  • Auditing skills a plus


Personal Characteristics:

  • Demonstrated ability to comprehend and apply compliance policies and procedures in day-to-day operations
  • Ability to prioritize, organize, and manage competing tasks with minimal guidance
  • Comfortable dealing with ambiguity and initiating corrective action plans when needed
Not Specified
Plant Operations Manager
Salary not disclosed
Simi Valley, CA 5 days ago

OCCUPATIONAL SUMMARY


Responsible for the overall safe and efficient plant operations of Gillibrand Industrial Sands, Inc. Manages and directs the activities of production, quality control and implements the strategy for the facility. Manages the operations associated with Industrial Sand and aggregate production, including quarrying, mining, processing, quality control, stockpiling, loading and shipping. Responsible for Environmental, Health and Safety (EHS) aspects of the facility, fixed and mobile equipment maintenance, and employee relations.


JOB DUTIES:


Operations Management:

· Oversee all aspects of Industrial Sand / Aggregate plant operations, including crushing, screening, washing, and material handling.

· Schedule and manage daily production to meet quality and volume targets.

· Monitor equipment performance and coordinate routine maintenance and repairs.

· Plans and schedules production requirements (people & equipment) to support daily, weekly, monthly, quarterly and annual sales forecast to meet customer’s needs.

· Identifies, assesses, prioritizes, and resolves production and employee-related problems.

· Manages production meetings on the daily operations of the plant.

· Walks throughout the operation daily and ensures the cleanliness of the entire facility.


Personnel Management:

· Manages and supervises activities of salaried and hourly production and maintenance employees.

· Actively involved in the selection, hiring, training, change of status, and separation of employees.

· Supervise, train, and evaluate plant staff (operators, technicians, laborers).

· Enforce company policies and safety protocols.

· Coordinate shift schedules and manage labor resources efficiently.

· Provides coaching and disciplinary counseling to employees under his or her area of responsibility (includes employee relations and administration of collective bargaining agreements region specific).

· Administers and enforces Company policies and procedures.


Safety & Environmental Compliance:

· Ensure adherence to MSHA, OSHA, and environmental regulations

· Conduct regular safety meetings, inspections, and incident investigations.

· Implement and maintain site-specific safety programs. Ensures that the plant meets all EHS policies and practices at the site location and works with EHS Regional employees and Company officials to promote a safe work environment that meets all State and Federal rules and regulations.

· Ensures that employees receive proper training and instructions to perform assigned job duties.

· Utilizes appropriate resources and recommendations in community relations and legislative efforts and actively participates in the area’s community outreach and educational programs.


Quality Assurance:

· Ensure product meets customer specifications and internal quality standards.

· Work closely with the quality control team to address deviations.

· Works closely with sales staff, quality control personnel, and customers to ensure that products meet customer needs and expectations.

· Works with sales on identifying and eliminating customer issues and concerns to improve customer satisfaction and relations.

· Participates in developing an annual operating budget, which includes production volume, maintenance expenses, and maintenance of business assets (replacement and critical spares), along with capital improvements.


Budget & Reporting:

· Manage the operating budget, track production costs, and seek cost-saving initiatives.

· Maintain accurate production records, maintenance logs, and compliance reports.

· Provide regular performance updates to senior management.

· Manages plant production operations to ensure cost efficiency, optimal plant and equipment utilization, and personnel allocation.

· Responsible for ensuring that the site meets or exceeds operating budget.

· Participate in Operation’s short- and long-range business planning.


Continuous Improvement:

·Identify and implement process improvements for efficiency and productivity.

·Support capital projects and equipment upgrades.

· Works on implementing cost-saving programs and/or continuous improvement activities to reduce costs and improve operating efficiency.

· Compiles data and provides information to analyze and recommends more cost-effective and technologically advanced methods of production processes.


QUALIFICATIONS

· BS degree in Engineering (Mining/ Civil, Mechanical/ Materials/ Mineral Processing); preferred or an equivalent combination of education and experience.

· Minimum of 5 years’ prior work experience in supervising production employees, preferably at either an Industrial Sand or Industrial Minerals mine. Construction materials industry experience preferred

· Knowledge and understanding of modern principles and practices of supervising production employees

· Thorough knowledge of plant operations and their associated products, processes, and related equipment.

·Strong knowledge of crushing, screening, separation, and material handling equipment.

· Knowledge of safety and environmental rules and regulations (MSHA and OSHA).

· Knowledge and understanding of business planning and financial forecasting requirements.

· Excellent leadership, communication, organization, conflict, and problem resolution skills.

· Proficient in Microsoft Office Suite and other software packages relevant to the position.

· Ability to plan and manage effectively using motivation and team-building skills.

· Flexible to work long hours and occasional overnight travel.

· Must represent the company in a professional manner to all customers, vendors, and internal employees.

· Other duties may be assigned as required


WORK DEMANDS AND ENVIRONMENT

· Personal protective equipment is required on a regular basis, as needed, including hard hat, hearing protection, eye protection, hard-toed safety shoes or boots, dust mask respirator, protective clothing, gloves, and other personal protective equipment.

· Employee may be exposed to dusty and noisy environments and may be working occasionally in extreme weather conditions including heat, cold, wind and rain.

· Work environment will be both indoors in an office and outside in the quarry or plant.

· In the office, will occasionally be required to sit at a desk or operator’s station. In the outside setting, will perform activities at various heights around moving machinery, be exposed to dust, fumes, and gases; may be required to use hand or power tools.

·Must be able to lift 50 lbs. and walk across uneven surfaces.

· Must have a valid driver’s license.

Not Specified
Personal Injury Intake Specialist
Salary not disclosed
Glendale, CA 4 days ago

A great opportunity to be a part of a reputable, and growing law firm handling significant cases in a positive work atmosphere. Our law firm needs an experienced Personal Injury Intake Specialist with strong sales experience and a desire to grow within the legal industry. The Intake Specialist will be the first point of contact with prospective clients, will screen leads, and will be responsible for obtaining case details that will allow the firm to determine if a case should be retained. We ask that you have a strong customer service background and possess the ability to screen potential client calls. You will ensure operational excellence and handle a large volume of incoming client calls.


Responsibilities:

  • Conduct initial client intakes
  • Persistently monitor all potential new client inquiries (email, internet, phone and referrals)
  • Immediately contact every potential client and establish relationship with client
  • Update logs and reporting systems to reflect status of all potential new clients
  • Conduct potential new client interviews with genuine empathy and compassion
  • Schedule appointments for potential clients
  • Take accurate notes during the initial intake
  • Collaborate with our attorneys to complete the initial consultation process
  • Assist attorneys with administrative tasks related to opening new cases and maintaining databases
  • Performs other related duties as assigned.
  • *The company reserves the right to add or change duties at any time.

Qualifications:

  • Strong attention to detail
  • Proven track record to meet goals and deadlines

Physical Requirements

  • Prolonged periods sitting at a desk and working on a computer.
  • Must be able to lift up to 15 pounds at times.


Work Location: In person

Pay: $20-$25 per hour

Not Specified
Production Manager
🏢 Tangent
Salary not disclosed
Winchester, VA 4 days ago

As the Production Manager - Lenoir at Tangent you will have the opportunity to directly impact the organization by overseeing a 24 x 7 facility manufacturing approx. 8 MM pounds of high-density polymer lumber a year and overseeing a staff of 20. Our Lenoir facility is the primary manufacturing location for our Marine Pile and Marine Timber product. As Production Manager you will manage multiple teams of operators throughout our 45,000 sq ft recycling facility. You will be responsible to hire, train and develop your team to meet the needs of the rapidly growing business.


ROLE AND RESPONSIBILITIES

  • Recruits, interviews, hires, and trains new staff.
  • Continues and enhances the existing team system
  • Oversees the daily workflow of the department.
  • Provides constructive and timely performance evaluations.
  • Handles discipline and termination of employees in accordance with company policy.

DUTIES/RESPONSIBILITIES:

  • Oversees Safety of the facility and ensures Safety policies are adhered to.
  • Responsible for Quality for the facility and that all Quality procedures are being followed.
  • Oversees production quotas and schedules, ensuring standards are met or limitations are being addressed.
  • Collaborates with purchasing department to verify, review, maintain, and report on materials and production inventories.
  • Facilitates and authorizes repairs or maintenance for production equipment and tools. Coordinates with Maintenance to minimize downtime
  • Train operators on expected operator maintenance duties.
  • Coordinate interplant material moves with company drivers.
  • Communicate with sales and production planning teams to ensure customer expectations are met.
  • Ensure continuous improvement process is maintained.
  • Identifies and recommends cost controls and other improvements to production process.
  • Performs other related duties as assigned.

REQUIRED SKILLS/ABILITIES

  • Excellent interpersonal and customer service skills.
  • Excellent organizational skills and attention to detail.
  • Excellent time management skills with a proven ability to meet deadlines.
  • Strong analytical and problem-solving skills.
  • Comfortable learning about processing equipment to facilitate both efficient operation, troubleshooting and repairs.
  • Strong supervisory and leadership skills.
  • Proficient with Microsoft Office Suite or related software.

EDUCATION AND EXPERIENCE

  • Bachelor’s degree in business, Industrial Management, Engineering or related field preferred.
  • At least four years of manufacturing experience required.


PHYSICAL REQUIREMENTS

  • Prolonged periods of sitting at a desk and working on a computer.
  • Must be able to lift up to 25 pounds at times.
  • Prolonged periods of walking and standing on production floor.
Not Specified
Director Process Development and Manufacturing, CMC
Salary not disclosed
Durham, NC 4 days ago

Job Title: Director Process Development and Manufacturing, CMC

Department: CMC

Reports to: Chief Technical Officer


About the Company:  

Opus Genetics is committed to building an innovative, efficient and sustainable science based and commercial ophthalmic biopharmaceutical company leading the development of transformative gene therapies for the treatment of inherited retinal diseases (IRDs) and therapies to treat patients with other retinal and refractive disorders.


Job Summary: 

The Director of Process Development and Manufacturing will be the technical lead for development and manufacturing of assigned assets within the Opus gene therapy programs focusing on technical transfer and process development and execution supporting product development and manufacturing to achieve company goals and strategies. This includes working collaboratively with external partners (i.e. CDMOs, contract labs, suppliers) to develop technical studies, analyze complex data, make data driven decisions, and author, review, and approve technical and regulatory documents. The ideal candidate will have a deep technical understanding of AAV gene therapy upstream and downstream development and process optimization.  This role will directly interact with the CDMO/contract partners and be responsible for building and maintaining excellent working relationships. Knowledge of manufacturing platforms, consistent with AAV technology, at scales ranging from process development through GMP and PPQ activities. The candidate will be hands-on and expected to provide content to all these areas. 

Duties/Responsibilities: 

·      Work with Opus CDMO/contract manufacturing and laboratory partners to develop a phase appropriate robust manufacturing program to support the process development and engineering of pre commercial and commercial cGMP material to support pre-clinical studies, clinical trials, and commercial supply. 

·      Support, author, and review/approve manufacturing plans and documentation including technical transfer, batch records and documentation, product specifications, stability programs, bridging and comparability studies, and other reports utilizing phase appropriate QbD best practices.

·      Support, author, and review/approve manufacturing documentation including testing records, certificates of testing/analysis, campaign summary reports, investigations, etc. 

·      Support, author, and review/approve regulatory documentation including pINDs, INDs, agency responses, CMC meeting requests and briefing packages, and BLAs.   

·      Ensure proper reference standard material is in place, tested, and released for each product. Lead technology transfer between sites. 

·      Ensure regulatory requirements are in place to support manufacturing campaigns with respect to Master Cell Banks, Plasmids, Drug Substances, Drug Products, and Diluents, to prevent developmental delays and or interruptions to clinical programs or regulatory filings.

·      Perform the role of person in plant as needed at the Opus CDMO/contract manufacturing partner’s sites. Act as the CMC expert during audits and interactions with regulatory agencies. 

·      Manage work to project plans for multiple gene therapy programs in the preclinical, pre-IND, IND/clinical, and commercial stages. 

·      Identify and lead the resolution of operational and functional level challenges, work with program and/or function managers to escalate issues to senior management.

·       Hands on resolution to issues/content generation. Design effective and high-quality presentations and progress reports, as requested.

  

Supervisory Responsibilities: 

·      None 

 

Education and Experience: 

·      Master’s degree (minimum) from an accredited institution in a science or health-related field with minimum of 7-10 years of experience in the pharmaceutical or biotechnology industry. Ophthalmology experience is preferred.

·      Additionally, a minimum of 5 years of direct manufacturing experience for biopharmaceuticals. Preference will be given for direct AAV gene therapy experience. Previous CDMO/contract lab experience also preferred.

·      Experience designing and executing technical transfer and scale up campaigns and associated documentation.

·      Experience in writing and reviewing regulatory submissions including pINDs, INDs, Meeting Requests/Briefing Packages, Annual Report/DSUR’s, and BLAs. 

·      Experience with FDA and/or other regulatory agency requirements and interactions.

·      Strong skill set in interacting with multidisciplinary teams for preclinical and clinical development. Clear understanding of the drug development process with experience in multiple phases.

·      Experience with Orphan/Rare Disease programs, and/or Fast Track/Breakthrough Therapy is a plus.

·      Demonstrated leadership skills and ability to influence across all levels of a cross-functional team without direct managerial authority. Experience in risk assessment, negotiation, and problem solving/mitigation.

·      Outstanding interpersonal skills, ability to communicate effectively in both oral and written form, with effective time management skills needed to manage multiple ongoing projects simultaneously.

·      Demonstrated advanced computer software proficiency (Word, Excel, Smartsheet’s, PowerPoint, etc.).  

Physical Requirements:  

·      Ability to travel 20% of time

·      Ability to work in laboratory settings/situations

·      Prolonged periods sitting at a desk and working on a computer. 

·      Must be able to lift up to 15 pounds at times. 

 

 

Location:

This position is currently based in the Durham North Carolina area; Hybrid/ remote options considered.

 

 Salary Range:


$190,000-210,000



The above job description is not intended to be an all-inclusive list of duties and standards of the position. Incumbents will follow any other instructions, and perform any other related duties, as assigned by their supervisor. 

 

Opus Genetics is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. 

 

Not Specified
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