Muscle Cell Function Jobs in Usa

• This is a remote field-based position that will cover the east coast. (Maine to Florida). Candidates should live in close proximity to a large airport hub within that geography.
  
  

• Function as the primary medical point of contact in geographic area.
• Maintain clinical and scientific, expertise in oncology with specific focus in standards of care related to the treatment of ALK + NSCLC.
• Engage in well informed, compliant, robust, and accurate scientific peer exchange around our client’s pipeline, with KOLs.
• Have a thorough understanding of the clinical protocols, clinical trials outcomes and related procedures.
• Develop and track key opinion leader (KOL) engagement plans - identify, develop, and maintain long-term collaborative relationships with KOLs within assigned region.
• Engage in medical & scientific exchange with the medical/scientific community including advisory boards.
• Responsible for ongoing territory management and development.
• Responsible for all clinical program requests and for unsolicited requests for information.
  • May collaborate with R&D Team to support sites and investigators participating in the company-sponsored clinical trials.
• Conduct pre-launch KOL profiling efforts to enhance depth of product/disease/scientific knowledge. Facilitate top account/institution profiling efforts to enhance understanding of patient care pathways, including treatment protocol development and novel therapies.
• Work collaboratively and compliantly with commercial colleagues to assure product strategic imperatives are represented cross functionally in account engagement.
• Respond to and document unsolicited requests for information on clinical initiatives.
• May serve as a resource for investigator sponsored trial (IIST) proposal.
• Provide internal teams with feedback and insights from interactions with KOLs.
• Represent our client at medical meetings through Medical Affairs’ Scientific Booth coverage and other related activities.
• Attend congresses as appropriate and develop meaningful internal reports of the congresses covered.
• Adhere to corporate SOPs and ensure vigilant compliance with relevant legal and regulatory guidelines governing scientific interactions with physicians and healthcare professionals across all activities, including those related to clinical trials, scientific interactions with internal and external groups, and responses to unsolicited requests for medical/scientific information.
• Consistently demonstrate a high standard of excellence in the management of assigned territory while also contributing to the success of colleagues and the MSL team.
• Willingness to contribute to the achievement of organizational goals beyond the borders of a geographic territory.
• Be solidly versed in the clinical data such that the full range of innovative science, clinical, outcome, economic and value aspects of our client’s products can be appreciated by the healthcare practitioner, formulary member or payer.
• Provide medical support, clinical input, and/or training for internal teams as requested.
  

• An advanced degree (e.g., PharmD, PhD, MD, MSN, or NP/PA) is required.
• MSL: A minimum of 2 years previous MSL experience necessary with a minimum of 1 year in rare disease, oncology (and/or immunology) with working knowledge of Gene Therapy.
• Sr. MSL: A minimum of 5 years of pharma experience and 3 years of rare disease, oncology (and/ or immunology) experience.
• Targeted Therapy experience strongly preferred.
• Prior product launch experience required.
• Exhibits the highest level of scientific, business, and clinical acumen with excellent communication and networking skills.
• The ability to interpret and present scientific data to engage KOLs.
• Working knowledge of standards of care for Alk + NSCLC is desirable.
• Previous experience sharing scientific content with payer systems is highly desirable.
• Working knowledge of NCI Cooperative Groups and Oncology Research Consortiums.
• Ability to present complex scientific and value and evidence data to payors and/ or formulary committees is required.
• Working knowledge of institutions and clinics in selected geographies is expected.
• Excellent written and oral presentation skills.
• Ability to travel frequently (70%) with overnight stays (e.g., KOL meetings, site locations, internal meetings, medical meetings and congresses, training).
  
  

• Patient Minded I act with the patient’s best interest in mind.
• Client Delight I own every client experience and its impact on results.
• Take Action I am empowered and empower others to act now.
• Embrace Diversity I create an environment of awareness and respect.
• Grow Talent I own my development and invest in the development of others.
• Win Together I passionately connect with anyone, anywhere, anytime to achieve results.
• Communication Matters I speak up to create transparent, thoughtful, and timely dialogue.
• Always Innovate I am bold and creative in everything I do.
  
  

Position Title: Manager, Clinical Imaging and Analysis

Previous Title: Manager, Sr. Laboratory Technologist – Imaging and Molecular Biology

Reports to: Sr. Director, Lab Operations and Systems Implementation

Company Background:

CNSide Diagnostics, LLC, a subsidiary of Plus Therapeutics, Inc., develops and commercializes proprietary clinical diagnostic laboratory tests, such as CNSide, designed to identify tumor cells that have metastasized to the central nervous system in patients with carcinomas and melanomas. The CNSide Cerebrospinal Fluid Assay Platform enables quantitative analysis and molecular characterization of tumor cells and circulating tumor DNA in cerebrospinal fluid, informing and improving the clinical management of patients. The Company is in the early stages of commercializing CNSide in the U.S.

Role:

This position collaborates with the Laboratory and Medical Directors to ensure high-quality laboratory testing in compliance with established policies, procedures, and CAP/COLA/CLIA standards. It also works closely with the Director of Operations to support and advance strategic business initiatives.

Responsibilities:

Microscopy & Image Analysis

• Oversee and perform tumor cell enumeration and analysis using multi-channel fluorescence imaging.
• Interpret fluorescent images across multiple channels, distinguishing true cellular signals from background, debris, or nonspecific staining.
• Apply standardized rules and reporting criteria for rare-event detection and maintain consistency across operators.

Quality & Documentation

• Maintain accurate, audit-ready documentation of test results, workflows, and quality control activities.
• Escalate unusual or borderline findings and collaborate with scientific teams on interpretation.
• Participate in inter-operator reproducibility assessments and QC investigations related to imaging performance.
• Ensure adherence to CLIA/CAP regulations and internal quality standards.

Workflow & Team Management

• Review images in accordance with batching schedules and laboratory throughput goals.
• Support testing operations by providing timely, accurate, and high-quality results.
• Train, mentor, and supervise laboratory personnel in imaging techniques, analysis workflows, and best practices.
• Manage operational priorities, workflow optimization, and process improvement initiatives for the imaging team.

Qualifications:

• Master’s degree in Molecular Biology, Biomedical Sciences, Cytotechnology, or a related life science discipline required; PhD with industry experience preferred
• 7+ years of relevant experience in cytology, histopathology, immunocytochemistry, diagnostic imaging, or related laboratory disciplines
• Demonstrated experience with fluorescent microscopy, multi-channel image analysis, and DNA FISH analysis
• Proficiency with professional image analysis platforms (e.g., Bioview, Zeiss, Olympus, Celigo, or equivalent)
• Experience working in regulated, clinical, or high-complexity laboratory environments (CLIA/CAP preferred)
• Ability to quickly learn and apply new imaging platforms, microscopy systems, and analytical workflows
• Strong written and verbal communication skills
• Demonstrated ability to manage multiple priorities, maintain attention to detail, and lead teams effectively in a fast-paced laboratory environment

Requirements:

• Understanding of clinical laboratory operations, high-complexity testing, and quality systems
• Working knowledge of good laboratory practices (GLP), documentation standards, and safety guidelines
• Demonstrated expertise in high complexity multicolor image analysis and an ability to troubleshoot technical and operational issues and implement workflow improvements
• Ability to learn and apply new imaging platforms, microscopy systems, and analytical workflows
• Strong analytical, problem-solving, written, and verbal communication skills
• Proven ability to manage multiple priorities, maintain attention to detail, and lead teams effectively in a fast-paced laboratory environment
• Ability to work independently and collaboratively across cross-functional teams
• Ability to stand, sit, walk, bend, reach, perform manual manipulation, and lift up to 10 pounds
• Ability to work in a laboratory and office environment and maintain a clean, orderly work area
• All laboratory personnel must pass a color vision test
• Adherence to department-specific safety and compliance requirements
• Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions

Plus Therapeutics, Inc. and CNSide Diagnostics, LLC are Equal Employment Opportunity employers and consider all qualified applicants without regard to protected status.

Industry: Pharmaceuticals

Title: Senior Associate Scientist

Job ID: CAMB000127

Location: Cambridge MA

Duration: 09 months contract (+Possibility of extension)

Overview

The experienced Research Associate Scientist II, with a background in in vitro screening, will be part of our dynamic, fast-paced and interdisciplinary lead development team. Our mission is to advance Client RNAi therapeutic programs from target discovery through lead candidate selection. The Associate Scientist II will be technically skilled in molecular and/ or cell biology, and bring a rigorous, analytical approach to research.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Perform cell culture (iPSCs, primary cells, immortalized cell lines) to support the research needs of the group and high-throughput screening of siRNAs using qPCR and a variety of cell-based assays
• Execute day to day operations for RNASeq sample preparation, including: library preparation, QC and sequencing. Maintain sample tracking & records.
• Conduct assays that support in vivo studies (e.g. qPCR, ELISA) for the quantitative analysis of biomarkers or siRNA activity
• Support lab maintenance including equipment operation & maintenance , reagent inventory and reagent preparation
• Troubleshoot technical problems and participate in the continuing development and optimization of existing and new protocols.
• Utilize instrumentation and robotics to aid in high throughput (384-well) screening.
• Adapts well to the changing platform needs, in workflow, projects and other tasks as required by the platform.

Qualifications

• A BS in a biological science with at least 2 years of hands-on laboratory experience in cell or molecular biology are required
• Experience in cell culture and purification/quantification of nucleic acids/protein, including qPCR
• Experience with NGS workflow is desired
• Experienced with laboratory automation including liquid handling systems such as Perkin Elmer JANUS, Beckman i7 or other systems.
• The candidate should be intensely detail oriented, highly motivated, capable of managing multiple projects simultaneously, desire to drive innovation, and willingness to learn
• We particularly seek someone who is detail oriented and who will flourish in a goal-driven team environment under tight deadlines.
• Excellent interpersonal skills with the ability to work well with others in a dynamic and highly collaborative environment.

Comment Must-Have Skills/Experience

• Cell culture (including iPSCs, primary cells, immortalized lines)
• Experience with qPCR and other cell-based assays
• At least 2 years of hands-on lab experience Nice-to-Have Skills
• Experience with RNA sequencing (RNASeq) – library prep, QC, and sequencing
• Familiarity with liquid handling systems/automation (e.g., PerkinElmer JANUS, Beckman i7)
• Exposure to NGS workflows
• Minimum Education Bachelor's degree in biology or related field Master's degree preferred, but not required Work Experience
• At least 2 years of lab experience (no fresh graduates)
• Needs to be comfortable working independently and multitasking in a fast-paced lab environment Soft Skills / Culture Fit - Proactive and dependable
• Able to work independently and figure things out without constant direction
• Easygoing but motivated and ambitious
• Strong communication and collaboration skills

Must-Have Technical Skills:

• Complex in vitro experience
• iPSC experience
• 3D models
• Mammalian cell culture
• CRISPR
• qPCR
• RNA work
• Transfection

Ray Therapeutics mission is to restore vision to people with retinal degenerations. RayTx is using a novel bioengineered optogenetic protein optimized for human vision delivered by AAV to restore visual function in a mutation agnostic approach and without the need for light enhancing eyewear. The company is developing its lead candidate RTx-015 in retinitis pigmentosa, a degenerative retinal disease with significant unmet medical need as well as a pipeline to treat both rare and large market indications.

We are currently seeking an exceptional team member to join our team as a CMC Technical Development Specialist. This role will report to the Senior Director, CMC Analytics, and will have an active role supporting the general CMC department as well as our process, product management, and MSAT teams. The position requires hands on support for AAV analytical development, transfer, and qualification through validation support for our lead candidates from Pre-IND to BLA. The role is based in the Berkeley, CA office with a hybrid work from home/in office requirement and may require travel to our external vendors at in the United States. If the lab is where your curiosity comes alive and breakthroughs spark your excitement, this position may be right for you.

The job duties and responsibilities include but is not limited to the following:

• Collaborate with analytical development and process development teams to develop, qualify and/or validate AAV gene therapy assays.
• Develop analytical methods and support method optimization/characterization.
• Independently execute analytical assays including molecular biology assays, chemical/biochemical assays, and cell-based biological potency assays, for internal CMC commitments, process monitoring, release and stability.
• Develop protocols for analytical transfer, qualification and /or validation studies and execute associated wetlab work.
• Present aasay methodology and principles to external partners and support method transfers.
• Execute routine assays with high presicion and provide data summaries and reports in a timely manner.
• Document all raw data, method plans, and summarize conclusions.
• Author and review Test Methods, Reports, and Protocols.
• Work in the lab independently and in a collaborative environment with minimal guidance.
• Support CMC outside of analytical teams to move programs forward, e.g. shelf-life determination, upstream characterization etc.

Qualifications and Experience:

• BA/BS in Biochemistry, Biology, bioengineering or a related fields and at least 10 years of Biotech/pharmaceutical industry experienced required.
• Experienced in compendial methods, CE-SDS, gel electrophoresis, HPLC, DLS, ddPCR or qPCR, ELISA, and cell based potency assays.
• Hands on experience in AAV gene therapy analytical methods and testing required.
• Experience in precision pipetting and cell culture (handling, aseptic techniques, maintenance), plate-based imaging, ELISAs, luminescence and fluorescence detection techniques.
• Curiosity and good scientific knowledge and acumen.

Compensation Range and Benefits:

• For this role, the anticipated base salary range: $145,000 to $160,000, based on the candidate's professional experience level. The final salary offered for this position may take into account a number of factors including, but not limited to skills, education, and experience.
• Ray Therapeutics also offers annual performance-based bonus, annual equity awards and a comprehensive benefits package.

At Ray Therapeutics, we celebrate diversity and are committed to creating an inclusive environment for all employees; providing an environment of mutual respect where equal employment opportunities are available to all applicants and teammates without regard to race, color, religion, sex, pregnancy, national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information, military and veteran status, and any other characteristic protected by applicable law.

All employment is decided on the basis of qualifications, merit, and business need.

Search Firm Representatives Please Read Carefully

Ray Therapeutics does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Please, no phone calls or emails.

Our large pharmaceutical client in Spring House, PA is seeking a passionate and talented lab-based Scientist to support the Immuno-Oncology (I-O) portfolio within the R&D organization. This position will be responsible for driving forward scientific research programs with novel assay implementation, generating translational data, and interrogating Immuno-Oncology assets in a dynamic research lab environment. The candidate will participate in a highly collaborative and interactive team atmosphere while executing experimental approaches to support preclinical biology and clinical assets. Primary responsibilities (include, but are not limited to):

• Design, perform, and interpret complex in vitro, ex vivo, and in vivo experiments
• Isolation and culture of primary cells from blood and tissue
• Execute multi-parameter flow cytometry (FACS) assays end-to-end including set-up and running of samples on the instrument & downstream analysis
• Design, develop, and perform robust in vitro cell assays that incorporate functional readouts, including activation, proliferation, cytokine production, and cytotoxicity
• Analyze and present data in professional 'publication ready' format
• Work independently and manage multiple experiments simultaneously
• Contribute to various projects outside of his/her own and collaborate with stakeholders from all relevant functions

Qualifications:

• Bachelor's or Master's Degree in Biology or related field of study
• 2+ years of tissue cell culture work experience
• Hands-on experience executing multicolor flow cytometry and western blot
• Background in oncology and/or immunology is strongly preferred

Salary: $78,000-$98,000 (flexible based on experience)

Hours: Monday-Friday, 8:00am-5:00pm

Hiring Method: 6 month-long contract with a high likelihood of extensions

PTO: 8 PTO Days & Paid Holidays

Benefits: Medical, Dental, Vision and 401K plans available

Exact compensation may vary based on several factors, including skills, experience, and education. Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.

ACCOUNTABILITY:

The position of Cell Leader is a key catalyst on a manufacturing Cell Team, who works in conjunction with Process Engineering, Quality Engineering, and hourly Cell associates to manufacture or assemble a component or major assembly. As such, this individual must supervise a group or groups engaged in various activities in the Operations organization, and act with urgency to direct the resolution of technical and logistics problems and the introduction of measures to improve operations and customer relations.

TYPICAL DUTIES:

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• Set work priorities aligned to satisfy company, customer demand and on-time delivery metrics. Collaborate with planner and peer Cell Leaders to schedule work through the various manufacturing work centers and manage work center to assure adequate flow of production. Manage line balance ensuring the pacing process is adequately staffed to maintain desired output levels. Hold direct reports accountable to meet Operating, OTD, Quality, and Safety metrics. Ensure direct reports are fully engaged performing value added work.
  
• Develop and implement action plans to meet department goals in the areas of labor efficiency, labor utilization, housekeeping, on-time delivery and productivity improvements. Perform regular daily audits of key processes to ensure optimum process performance and use of latest operation sheets,
  
• Maintain department/cell metrics. Ensure all direct reports understand their cell metrics and how they impact/improve each metric. Monitor Utilization rate in cell is at acceptable level (direct vs. indirect), Labor Efficiency (by person, by job), Quality Performance (Maintain Quality log), enforce work rules (breaks, cell phones, newspapers, etc.), ensure TPM/PM is being completed.
  
• Coach direct reports in maintaining accurate reporting of employee time, vouchering and work performance within the area. Develop and maintain Skills Matrix for accurate identification of workforce capabilities and cross train to support business need.
  
• Encourage employee involvement in and ownership of continuous improvement activities focused on LEAN and waste reduction. Implement and maintain 6S in Cell.
  
• Develop, plan and implement continuous quality improvement through teams within the area of responsibility to attain World Class Quality. Ensure PDR's are written quickly & thoroughly. Initiate PRB review on suspect parts in a timely manner. Support weekly PRB meetings to determine RCCA and develop rework scenarios where possible. Respond to production problems by personally investigating and resolving such problems with hourly and salaried personnel to assure a continuing flow of product. Utilize formal problem solving methodologies to discover and eliminate root cause.
  
• Actively participate, recommend, and initiate improvement in our EH&S practices and procedures.
  
• Reward and recognize associates on a regular basis and support programs that encourage employee involvement and recognition.
  

QUALIFICATIONS:

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• 5-10 years' experience working in an aerospace manufacturing environment
  
• Prior experience in a unionized facility is preferred
  
• Proficient in Microsoft Office applications
  
• Excellent process and problem solving skills
  
• Effective communication skills, including verbal (logical and organized), written, listening and presentation
  
• Experience with ERP systems
  
• Team player with strong people skills
  
• Ability to communicate with and influence employees and management at all levels
  
• Decisive and capable of dealing with conflict and resolving issues promptly
  
• Take charge individual with clear sense of urgency
  
• Proven track record of meeting commitments with the highest standards of ethics and integrity
  
• Demonstrated experience in continuous improvement initiatives, root cause corrective action methodology, visual factory management, statistical process control techniques, quality assurance processes, coaching and performance management, safety practices, operations metrics/dashboard measurement.
  

EDUCATION:

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• Bachelor's degree in Operations Management, Business Management or equivalent work experience will be considered.
  

This position is currently accepting applications.

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