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The Department of Pharmacology and Neuroscience, Creighton University School of Medicine in Omaha, NE, is seeking a postdoctoral fellow for a project funded by NIH.
Key Responsibilities
Airway hyperresponsiveness andairway inflammation are hallmarks of asthma that is clinically managed with 2-agonist bronchodilatorsand inhaled corticosteroids. Refractory asthma manifests with persistent symptoms despite the use of high-dose oral corticosteroids and long-acting 2-agonists and poses a major healthcare challenge. Understanding the molecular mechanisms of therapeutic resistance and developing strategies to overcome such resistance poses a significant unmet need.
We are seeking a talented, highly motivated individual who is broadly interested in the molecular and cellular basis of refractory asthma. Our research focuses on understanding the molecular mechanisms of therapeutic resistance and developing new strategies to overcome such resistance inrefractory asthma.
An ideal candidate will be expected to develop the project independently and will also have the opportunity to interact and participate in other studies of our multidisciplinary group in the lab and throughout the department. Our research team highly values creativity and independence in a collaborative and collegial academic environment.
A successful candidate will have a doctorate in areas related to cell and molecular biology, immunology, signal transduction, and asthma supported by strong publications. Prior experience in airway smooth muscle cells and mouse models of asthma would be advantageous.
The candidate will also be asked to assist in training of laboratory staff and graduate students in research techniques as well as writing grant proposals. This is a full time, grant funded role.
Qualifications
- Applicants should have a Ph.D., M.D., or M.D./Ph.D. degree
- One year of related experience
- Significant research accomplishments and scholarly promise
How to Apply: Include the below 3 items to application for consideration.
- Curriculum vitae
- A brief summary of research to date and preferred research directions for the next few years
- Names of three referees who can write letters of recommendation (at least one outside the applicant's home institution)
Creighton University is a private research university in Omaha, Nebraska, USA. Founded in 1878, its ranking in the 2022-2023 edition of Best Colleges is #115 of National Universities, and #90 in Best Value Schools in USA.
AAP/EEO Statement:
Creighton University is committed to providing a safe and non-discriminatory educational and employment environment. The University admits qualified students, hires qualified employees and accepts patients for treatment without regard to race, color, religion, sex, marital status, national origin, age, disability, citizenship, sexual orientation, gender identity, gender expression, veteran status, or other status protected by law. Its education and employment policies, scholarship and loan programs, and other programs and activities, are administered without unlawful discrimination.
Disclosure Statement:
This description describes the general nature of work to be performed and does not include an exhaustive list of all duties, skills, or abilities required. Regular, reliable attendance is an essential function and all employees are required to follow any other job-related instructions and to perform any other job-related duties as requested by their supervisor. Employees may also be required to work in excess of normal working hours as workloads and seasonal activities necessitate. A complete description is available in the Human Resource office located at 3006 Webster Street Omaha, NE. Creighton University reserves the right to modify duties, responsibilities and activities at any time with or without notice.
Dr. Nizar Saad’s lab is seeking a postdoctoral scientist to join a translational research program advancing RNA-based and genome-editing therapies for rare genetic diseases. The lab develops RNA-, and CRISPR-based approaches for laminopathies and muscular dystrophies, using viral and non-viral delivery platforms (i.e., AAV and extracellular vesicles (EVs)). The lab also leads EV-based biomarker discovery efforts in muscular dystrophies. This position will require experience in EV and/or AAV isolation, purification, and characterization, -omics workflows, mouse work, including dosing and tissue collection. Experience in EV and/or AAV engineering is desired. Experience in cardiovascular or skeletal muscle biology is preferred. Additional details:
- NIH-funded grant: Lab page: functions
- Conducts research under the guidance of a faculty mentor.
- Assists in the training and supervision of technical support staff in performing research essential to carrying out the research program.
- Records and analyzes data generated by the research study. Assists in the development of hypotheses for further investigation from the results of the studies performed.
- Assists with the preparation of scientific and technical papers for publication in peer-reviewed journals.
- Presents findings at local and national research forums.
- Collaborates with other ongoing research efforts either at NCH or at The Ohio State University.
- Works toward research independence, preparing to submit proposals to and obtain funding from external granting agencies.
Education
- PhD in relevant scientific field.
Qualifications
- Effective interpersonal skills required in interactions with scientists, physicians, and laboratory colleagues.
- Ability to work independently, and to proactively manage and lead projects.
- Strong data analysis, interpretation, and scientific communication skills.
- Skills in qualitative and quantitative research methods.
- Prior experience in molecular biology and Extracellular vesicle research.
- Track record of productivity (papers, presentations).
Required Skills
- PhD in molecular biology, genetics, bioengineering, or a related field.
- Strong background in molecular and cellular biology techniques (e.g., cloning, transfection, qPCR, Western blotting, immunofluorescence).
- Experience with mammalian cell culture (primary cells and/or immortalized cell lines).
- Hands-on experience with extracellular vesicle (EV) isolation, purification, and characterization.
- Experience with proteomics workflows (e.g., mass spectrometry–based proteomics).
- Experience with transcriptomic approaches (bulk RNA-seq and/or small RNA-seq).
- Basic bioinformatics skills for proteomic and transcriptomic data analysis.
Preferred Skills
- In vivo mouse work, including dosing and tissue collection.
- Experience with EV engineering and cargo loading strategies.
- Familiarity with muscular dystrophies or neuromuscular disease models.
- Experience with viral and non-viral gene delivery platforms (e.g., EV, AAV).
- Experience with biomarker discovery pipelines and translational research.
