Us Senior Software Developer Salary Jobs in Usa

8,219 positions found — Page 5

Mid-Tier Application and Database Developer
Salary not disclosed
Philadelphia, PA 4 days ago
About Us

AGE Solutions is a premier technology and professional services company, providing in-depth consulting, advanced technology solutions, and essential services throughout the U.S. government, defense, and intelligence sectors. Prioritizing innovation and client-focused solutions, we assist major agencies in addressing intricate issues and ensuring a more secure future.

AGE is seeking a Software Developer with strong C# and database expertise to join our development team. This role focuses on building and maintaining robust middle-tier services and data-driven applications. The candidate will work closely with cross-functional teams to design, develop, maintain and optimize scalable backend systems that power critical business functionality.


The ideal candidate combines solid middle-tier development experience with deep database development knowledge and a strong understanding of system design, performance, maintainability, and data integrity.


This role is hybrid in Philadelphia, PA, requiring onsite reporting at the customer's facility at least 1 day/week. Candidates must reside within a commutable distance of Philadelphia, PA in order to work onsite as required.


Responsibilities Include:



  • Design, develop, and maintain middle-tier services and backend components using C# and .NET technologies.
  • Apply SOLID principles and clean architecture practices in application design.
  • Build robust APIs and business logic layers to support web and enterprise applications.
  • Collaborate with front-end developers, architects, and DevOps teams to deliver integrated solutions.
  • Design, develop, optimize, and maintain relational databases (Oracle preferred).
  • Write efficient stored procedures, views, functions, and complex queries.
  • Optimize database performance, indexing strategies, and query tuning.
  • Participate in code reviews and enforce best practices for clean, maintainable code.
  • Troubleshoot and resolve production issues related to application logic and data layers.
  • Contribute to architectural decisions and technical design discussions.
  • Document technical designs and implementation details.

Required Skills, Qualifications and Experience:



  • BA/BS in technical discipline.
  • 10 years of experience in middle-tier and database development.
  • Experience in applying SOLID principles and object-oriented design patterns.
  • Strong proficiency in C# and .NET (.NET Core/.NET 6+) and ASP.NET Web API.
  • Experience designing and building RESTful APIs and middle-tier services.
  • Experience with ORM frameworks (Entity Framework preferred, Dapper).
  • Strong SQL skills and experience with relational databases (Oracle preferred, SQL Server, PostgreSQL).
  • Experience writing and optimizing complex queries and stored procedures.
  • Strong understanding of data modeling and database design principles.
  • Experience with version control systems (TFVC and Git).
  • Strong problem-solving skills and attention to detail.
  • Must be a United States citizen with a DoD Secret clearance or ability to obtain a favorably adjudicated T3 investigation.

Preferred Qualifications:



  • Experience with microservices architecture
  • Experience with CI/CD pipelines and DevOps best practices
  • Experience with cloud platforms (Azure preferred)
  • Experience with caching strategies (Redis, in-memory caching)
  • Experience with performance profiling and monitoring tools
  • Experience with containerization (Docker, Kubernetes)
  • Experience with automated testing frameworks

Work Environment and Physical Demand:



  • Must be able to work for extended periods of time at a computer.

Compensation: $115,000+

At AGE Solutions, we reward performance, invest in growth, and share success. Our benefits support the whole person, professionally, financially, and personally.



  • 26 Days Paid Leave: Includes vacation, sick, personal time, and holidays. You choose how to use it.
  • Performance Bonuses: Performance bonuses are awarded based on individual contributions and company-wide results, aligning recognition with impact.
  • 401(k) with Match: We match 3% of your contributions with immediate vesting.
  • Financial Protection: Company-paid life insurance up to $300K and options for additional coverage for you and your dependents.
  • Health Benefits: Multiple medical plans, dental, vision, FSA and HSA options to fit your needs.
  • Parental Leave: 15 days of fully paid leave for new parents, because family matters.
  • Military Differential Pay: We bridge the gap for employees on active duty, so they don't take a financial hit while serving.
  • Professional Growth: Paid training and certifications, tuition reimbursement, and the tools and tech to get the job done right.
  • Shared Success: In the event of a company sale, our CEO has committed to returning 80% of net proceeds to employees. This ensures our team shares in the long term value they help create.

At AGE, you'll do work that matters, supported by a company that delivers for its people.

Not Specified
Senior Java Software Engineer
Salary not disclosed
Sunnyvale, CA 2 days ago

Title: Senior Software Engineer Backend

Location: Sunnyvale, CA - Hybrid

Duration: 3-months, team extends quarterly

Please note! There are interim nights worked, once a week.


Our client is seeking a talented and passionate Staff, Software Engineer - Backend to join their team. The ideal candidate will have experience working in a large project environment with solid technical leadership abilities and strong development background in Java along with experience Cloud Implementation architecture and a proven track record of delivering high-quality scalable software applications.


Required Skills & Experience


  • 7-10 years experience
  • 60–70% coding, 20–30% design/architecture
  • Technologies: Java, SpringBoot, Kafka, CosmosDB, Bigquery, and Kubernetes
  • Owns design, ensures scalability
  • Confident in pushing designs to production
  • Tests own code
  • Participates in cross-team contract discussions


Job Description


  • Provide deep technical expertise and thought leadership that helps accelerate adoption of the absolute best engineering practices, while maintaining knowledge on industry innovations, trends, and practices.
  • Lead and participate in medium to large-scale projects by reviewing project requirements, translating requirements into technical solutions, gathering requested information, writing, and developing code, and conducting unit testing. Communicating status and issues to team members and stakeholders.
  • Developing highly scalable services to process millions of requests per day and solve complex software systems problems by leveraging state-of-the-art technology.
  • Gaining exposure to various technologies used in Marketplace and E-commerce platforms.
  • Designing and developing backend microservices and APIs for web applications using JVM ecosystem (Kotlin, Java) and other languages and frameworks (Python, Go)
  • Collaborate with project teams and cross functional teams. Troubleshoot open issues and bug-fixes, ensuring on-time delivery and hand-offs. Interact with project manager to provide e input on project plan.
  • Troubleshoot business and production issues by gathering information (for example, issue, impact, criticality, root cause), engaging support teams to assist in the resolution of issues. Formulate action plans, performing actions as designated in the plan. Interpret the results to determine further action, perform root cause analysis to prevent future occurrence of issues and complete online documentation.
  • Provide support to the business by responding to users' questions, concerns, and issues (for example, technical feasibility, implementation strategies). Facilitate resolutions and lead cross-functional partnerships.
  • Driving projects of high visibility across the organization.


Compensation: $50-$60/hour, depending on experience


Exact compensation may vary based on several factors, including skills, experience, and education. Benefit packages for this role will start on the 1st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.

Not Specified
Contract ODI Developer - Hybrid Onsite in Boston MA - USC OR GC ONLY
✦ New
Salary not disclosed
Boston, MA, Hybrid 1 day ago
Please send current resumes directly to
Bhagyashree Yewle, Principal Lead Recruiter - YOH SPG
ODI Developer - Hybrid Onsite in Boston MA - USC OR GC ONLY (No Visas)
  • Location: Boston, MA
  • Hybrid: 3 days on site
  • Potential Convert: Yes, USC/GC ONLY no exceptions. WILL NOT SPONSOR
Tope 5 Must haves:
  • ETL/ELT
  • ODI
  • PL/SQL coding
  • 7 years’ experience
  • Knowledge on how to be an admin side of things (not day to day but is able to do that)
  • Scripting – Python & Unix Scripting
Role Overview:
Seeking a highly skilled and experienced Sr. ODI Developer to join our Private Banking Systems team. The ideal candidate will possess expertise in a range of technologies, including ODI (Oracle Data Integrator), Oracle Data Warehouse, Linux, Python scripting, and have a deep understanding of the Banking domain is a big plus. As a Data Engineer, you will play a pivotal role in designing, developing, and maintaining data solutions.

Key Responsibilities:
  • Build ODI mappings/interfaces, packages, procedures, scenarios, topology configuration, ODI Agent and load plans to integrate data from multiple enterprise systems.
  • Expertise in building Pl/SQL queries, procedures, data loading process, ensuring high-performance and scalability to meet the evolving data needs of the various applications.
  • Design, develop, and maintain ETL/ELT pipelines using Oracle Data Integrator (ODI).
  • Collaborate effectively with cross-functional teams, including other data engineers, DBA group, analysts, and business stakeholders, to understand data requirements and deliver solutions.
  • Monitor and troubleshoot RMJ jobs, ODI workflows, sessions, agents, and data pipelines on Linux environments.
  • Perform root cause analysis for failures related to ODI workflows, RMJ jobs, network connectivity, API integrations, and file transfers.
  • Optimize ETL workflows to improve reliability, performance, and scalability.
  • Use scripting and automation tools to support data processing and operational workflows.
  • Work in Linux/Unix environments, using command-line tools and shell scripts for job automation and troubleshooting.
  • Maintain comprehensive documentation of data processes, configurations, and best practices.
  • Participate in walk-throughs which review program specifications, source code, and all technical supporting documentation, including screens/reports. Provide feedback in accordance with team standards and guidelines.
  • Participate in implementation of changes, enhancements, and newly developed programs.
  • Conduct technical research and provide recommendations, develop proofs of concept or prototypes, contributing to technical design of applications.
  • Helping to identify coding patterns and anti-patterns and enforce implementation of the patterns through code reviews.
  • Quickly resolving issues encountered by business lines in the production environment, maintaining a helpful, "high touch" approach to working with business users, performing root cause analysis, technology evaluation, and performance tuning.

Desired Qualifications:

  • Degree in Computer Science, Engineering or related technical area
  • 7+ years of extensive hands-on experience in ODI, Oracle Datawarehouse, Oracle PL/SQL, Linux, Python scripting, and ODI admin module (ODI Agent setup, logs configuration, certificate installation).
  • Must have experience in building Pl/SQL queries for Oracle Server (incl. stored procedures, functions…) and must understand basic principles of data modeling
  • Excellent collaborative and communication skills, particularly in high-stress situations
  • Experience with scripting Python and Linux scripting, CLE, networking fundamentals (API, IP/ports, SFTP/FTP connectivity)
  • High proficiency in development practices: unit testing, Continuous Integration (CI/CD), refactoring, clean code
  • Experience with Bitbucket/GIT source control management
  • Problem solving skills, able to determine upcoming risks & issues and address them accordingly.
  • Ability to interpret and troubleshoot applications using logs.
  • Pro-active approach and good communication skills.
  • Experience with agile methodologies (Scrum, Kanban) and tools (Jira)
Nice to Have:
  • Private Banking domain experience.
  • Working experience in a financial service industry
  • Financial application knowledge like FIS AddVantage, CRD, CRM Pivotal.
  • Experience with Apache Airflow for workflow orchestration.
  • Knowledge of dbt (Data Build Tool) for modern data transformations.
  • Exposure to cloud data platforms or hybrid data architectures.

Key Competencies:

  • Strong analytical and problem-solving skills
  • Ability to work with large-scale enterprise data environments
  • Excellent collaboration and communication skills
  • Ability to manage multiple priorities in a fast-paced environment
  • Commitment to continuous learning and technology innovation

Estimated Min Rate: $55.00

Estimated Max Rate: $72.00

What’s In It for You?
We welcome you to be a part of the largest and legendary global staffing companies to meet your career aspirations. Yoh’s network of client companies has been employing professionals like you for over 65 years in the U.S., UK and Canada. Join Yoh’s extensive talent community that will provide you with access to Yoh’s vast network of opportunities and gain access to this exclusive opportunity available to you. Benefit eligibility is in accordance with applicable laws and client requirements. Benefits include:

  • Medical, Prescription, Dental & Vision Benefits (for employees working 20+ hours per week)
  • Health Savings Account (HSA) (for employees working 20+ hours per week)
  • Life & Disability Insurance (for employees working 20+ hours per week)
  • MetLife Voluntary Benefits
  • Employee Assistance Program (EAP)
  • 401K Retirement Savings Plan
  • Direct Deposit & weekly epayroll
  • Referral Bonus Programs
  • Certification and training opportunities

Note: Any pay ranges displayed are estimations. Actual pay is determined by an applicant's experience, technical expertise, and other qualifications as listed in the job description. All qualified applicants are welcome to apply.

Yoh, a Day & Zimmermann company, is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Visit to contact us if you are an individual with a disability and require accommodation in the application process.

For California applicants, qualified applicants with arrest or conviction records will be considered for employment in accordance with the Los Angeles County Fair Chance Ordinance for Employers and the California Fair Chance Act. All of the material job duties described in this posting are job duties for which a criminal history may have a direct, adverse, and negative relationship potentially resulting in the withdrawal of a conditional offer of employment.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

By applying and submitting your resume, you authorize Yoh to review and reformat your resume to meet Yoh’s hiring clients’ preferences. To learn more about Yoh’s privacy practices, please see our Candidate Privacy Notice:  working/work at home options are available for this role.

contract
Javascript Developer
✦ New
Salary not disclosed
Denver, CO 1 day ago

Job Title: Senior React Developer

Location: Denver, Colorado, United States

Duration: Long Term Contract


About VLink: Started in 2006 and headquartered in Connecticut, VLink is one of the fastest growing digital technology services and consulting companies. Since its inception, our innovative team members have been solving the most complex business, and IT challenges of our global clients.


This is a hands-on consulting role focused on designing and delivering high-quality, scalable, and performant front-end solutions using React and TypeScript.

The ideal candidate brings deep front-end engineering expertise, strong architectural instincts, and the ability to collaborate closely with UX, backend engineering, and cross-functional stakeholders to deliver enterprise-grade digital applications.


How you'll make an impact

  • Design and implement modular, high-quality front-end features using React and TypeScript
  • Establish and maintain scalable front-end architecture supporting long-term maintainability and growth
  • Develop reusable Node.js modules and shared libraries to drive cross-project consistency
  • Build intuitive, accessible user interfaces leveraging Material UI or comparable design systems
  • Integrate applications with RESTful and/or GraphQL APIs, optimizing data access and state management
  • Implement comprehensive UI testing strategies using Jest, Cypress, React Testing Library, or similar tools
  • Optimize build performance and bundle efficiency through modern tooling such as Webpack and related technologies
  • Ensure solutions meet enterprise standards for performance, accessibility, and security
  • Partner with backend engineers to define API contracts and improve data-fetching strategies
  • Troubleshoot complex UI, caching, and state management challenges
  • Contribute to technical design discussions, conduct code reviews, and mentor junior developers
  • Stay current with evolving front-end trends, frameworks, and best practices


What you'll bring

  • 10+ years of front-end engineering experience, including significant production experience with React
  • Deep proficiency in TypeScript with strong understanding of scalable typing patterns and coding standards
  • Experience implementing enterprise UI design systems such as Material UI or similar frameworks
  • Working knowledge of Node.js, including development of shared packages or internal libraries
  • Hands-on experience implementing automated front-end testing strategies
  • Strong understanding of modern build tooling, module bundling, tree shaking, and performance optimization techniques
  • Experience with state management libraries such as Redux, Zustand, Recoil, or similar tools
  • Proven ability to improve application performance through lazy loading, code splitting, and bundle optimization
  • Experience integrating RESTful services and/or GraphQL APIs with efficient data handling strategies
  • Familiarity with CI/CD pipelines and release management practices for front-end deployments
  • Strong analytical and troubleshooting skills in complex client-side environments
  • Effective communication skills and ability to collaborate across product, design, backend engineering, and business teams


Strongly Preferred

  • Experience with AEM Cloud and SPA Editor
  • Familiarity with server-side rendering frameworks such as Next.js
  • Experience working within micro-frontend or modular front-end architectures
  • Knowledge of accessibility standards (WCAG) and advanced front-end performance optimization techniques
  • Prior consulting or client-facing experience



Employment Practices:

EEO, ADA, FMLA Compliant

VLink is an equal opportunity employer. At VLink, we are committed to embracing diversity, multiculturalism, and inclusion. VLink does not discriminate on the basis of race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law. All aspects of employment including the decision to hire, promote, or discharge, will be decided on the basis of qualifications, merit, performance, and business needs.

Not Specified
Lead Python Backend Developer
Salary not disclosed
Dallas, TX 2 days ago

We are seeking a Senior Lead Developer to lead the development and deployment of our backend services. In this role, you will be the bridge between our PostgreSQL database and React frontend, responsible not only for writing high-performance Python code but also for architecting the CI/CD pipelines that bring our applications to life. You will ensure our integration layers are scalable, secure, and automatically deployed.

Key Responsibilities

• API & Backend Development: Design and maintain production-grade RESTful APIs using Python (FastAPI, Flask) with a focus on asynchronous processing.

• Database Engineering: Architect relational schemas and write optimized SQL in PostgreSQL, ensuring data integrity and query performance.

• React Integration: Partner with frontend teams to define API contracts, handle state-consistent data fetching, and implement secure authentication (JWT/OAuth2).

• CI/CD & Deployment: Build and manage automated deployment pipelines (e.g., Azure DevOps or Jenkins) to move code from local environments to staging and production.

• Containerization & Cloud: Package applications using Docker and manage deployments on cloud platforms or container orchestrators (Kubernetes/ECS).

• System Reliability: Implement automated testing (PyTest), logging, and monitoring to ensure high availability of integration services.


Technical Requirements

• Experience: 10+ years of professional backend development with a heavy emphasis on Python and API architecture.

• PostgreSQL Expert: Advanced SQL knowledge, including indexing strategies, migrations (Alembic/Flyway), and performance profiling.

• DevOps Tooling: Hands-on experience with Docker and building CI/CD pipelines for Python applications.

• Frontend Literacy: Solid understanding of React (Hooks, Context API) and how it consumes complex JSON structures.

• Infrastructure as Code (Bonus): Familiarity with Terraform or AWS CloudFormation is a significant plus.


The "Lead" Expectation

At the 10-year mark, we expect more than just "feature delivery." We are looking for a candidate who:


• Automates Everything: If a task is done twice, they write a script or a CI job for it.

• Designs for Failure: Implements proper error handling, retries, and health checks in the API layer.

• Collaborates Across the Stack: Can jump into a React component or a Postgres execution plan to find the root cause of a bottleneck.

Not Specified
Mainframe Developer
✦ New
Salary not disclosed
Wilmington, DE 1 day ago

Job title: Sr Mainframe Developer

Client address: 880 Powder Mill Rd, Wilmington, DE, 19803


Job Description:

  • Develops and implements solutions that address complex business challenges, enhancing the ability to make data-driven decisions and improving operational efficiency.
  • Prepares architecture and design documents for complex Banking applications keeping in mind design constraints that translate to coding.
  • Develops secure and high-quality code that runs in sync with other highly efficient sub systems.
  • Think out-of-the-box proactively and be creative by challenging conventional approaches and contribute towards operational efficiency.
  • Troubleshoots problems, works with Product Teams and other stake holders to understand complex Requirements and be able to break them down to design/development


Job Requirements:

  • Candidate should have expertise in MQ, CICS, IMS, COBOL, JCL, VSAM & DB2. · Expertise in CICS Programming including knowledge of CICS Screen Programming is Mandatory.
  • Experience/Knowledge in building and maintaining new Test regions is preferred.
  • Experience coding in MQ Series & IMS DB is Mandatory.
  • Experience in Banking Compliance and Regulatory Platform is preferred.
  • Must have hands-on coding development experience. Experience with version control.
  • Ability to communicate effectively with team members and clients and excellent problem-solving skill


Years of experience required: 10-14

Not Specified
Full Stack Developer
Salary not disclosed
San Rafael, CA 2 days ago

Are you an experienced Full Stack Developer with a desire to excel? If so, then Talent Software Services may have the job for you! Our client is seeking an experienced Full Stack Developer to work at their company in Minneapolis, MN.


Position Summary: The team builds and maintains scalable microservices and batch-processing platforms that ingest, enrich, store, and serve user-generated content for clients' eCommerce and enterprise systems. Our culture is highly collaborative, prioritizing agility, code simplicity, operational excellence, and consistently high-quality software delivery.


Primary Responsibilities/Accountabilities:

  • Delivers complex, well-tested, and reliable product features with minimal oversight.
  • Excels at breaking down large problems and demonstrates depth across software development lifecycle phases, including concept, design, testing, and deployment.
  • Develops solutions and optimizations that improve performance across the full application stack.
  • Comfortable independently triaging complex issues across multiple environments in a fast-paced, dynamic setting.
  • Actively engages in pair programming, daily standups, sprint retrospectives, backlog grooming, and user story mapping.


Qualifications:

  • 5+ years of experience building highly scalable, high-performing applications using Java, Spring Boot, and Gradle with strong object-oriented design skills.
  • Experience with Test Driven Development (TDD), including writing unit and integration tests using JUnit, Mockito, and/or the Spock Framework.
  • Experience with streaming and messaging platforms such as Kafka, RabbitMQ, or Google Pub/Sub.
  • Strong experience with CI/CD pipelines using tools such as Jenkins or GitHub Actions.
  • Experience designing distributed application architectures that leverage NoSQL data stores such as Apache Cassandra for high throughput at scale.
  • Experience with search and indexing systems such as Apache Solr for large-scale data access and query performance.


Preferred:

  • Strong communicator and collaborator who works effectively across cross-functional teams, proactively brings ideas to the table, and takes initiative rather than waiting to be directed.
  • Experience with front-end technologies, including JavaScript, ReactJS and NodeJS.
  • Experience with container platforms such as Docker.
  • Experience designing, testing, and deploying scalable solutions on Google Cloud Platform utilizing services such as BigQuery, Cloud Functions, Cloud Run, and Dataflow.
  • Experience with off-heap caching solutions such as Memcached.
  • Experience leveraging AI-assisted development tools such as GitHub Copilot to accelerate development workflows.
  • Ability to triage and manage complex, production issues
permanent
Back End Developer
🏢 Talent Software Services
Salary not disclosed
Richfield, MN 2 days ago

Are you an experienced Back End Developer with a desire to excel? If so, then Talent Software Services may have the job for you! Our client is seeking an experienced Back End Developer to work at their company in Richfield, MN.


Position Summary: We are seeking a DevOps Engineer to join our Enterprise API Management team. The successful candidate will be responsible for building, deploying, and operating our platform and services, with an emphasis on automation, reliability, and secure-by-default delivery. This role partners closely with engineers through collaboration and pair programming to improve CI/CD pipelines, troubleshooting practices, and operational readiness, and it also requires some software development experience (e.g., ability to read/debug code and contribute when needed). Technologies involved include Kubernetes, Helm charts, Java/Spring Boot, AWS offerings (certification preferred), and API platform capabilities such as API Gateway and security.


Qualifications:

  • Kubernetes 5+ Years
  • Helm Charts 4+ Years
  • AWS (core offerings; certification preferred) 5+ Years
  • Java and Spring Boot 5+ Years
  • API Security 5+ Years


Preferred:

  • CI/CD and GitOps
  • Infrastructure-as-Code experience (e.g., Terraform/CloudFormation)
  • API Gateway/API Management experience
  • Observability tooling (logging/metrics/tracing) and on-call readiness
  • Lua Programming
  • Collaborative delivery practices (pair programming, code reviews)
Not Specified
Java Application Developer
✦ New
Salary not disclosed
Frisco, TX 1 day ago

Job Title: Java Developer

Location : Frisco, TX or Edison, NJ (Onsite Role-5 Days Onsite Per week)

Duration : 12+ Months Contract

Teams Meeting Interview

Job Description:


Weekend Drive this week for F2F interview and W2


Java developer - Need to go in person interview.



  • looking for 6+ years of candidate
  • Full‑Stack Development
  • Microservices architecture
  • CI/CD
  • Kafka / MQ
  • MongoDB
Not Specified
Sr Research Associate
🏢 Talent Software Services
Salary not disclosed
Novato, CA 3 days ago

Are you an experienced Sr Research Associate with a desire to excel? If so, then Talent Software Services may have the job for you! Our client is seeking an experienced Sr Research Associate to work in Novato, CA.


Position Summary: The selected candidate will work in the Separations and Biophysical Assays team within the Analytical Sciences group to assist in the advancement of clients' therapeutics for clinical evaluation and potential commercialisation. The candidate will be responsible for method development (separations), provide routine testing and characterization support to partner groups to help with early candidate selection, process development, and drug substance and drug product process characterization. The ideal candidate will have hands-on experience working with biologics including but not limited to proteins, peptides, protein-conjugates, enzymes, biologics with a focus on method development and in-depth characterization. The ideal candidate will be able to perform quality work under limited supervision, apply problem solving techniques to maintain accurate results, promote improvements, and assure a safe, stable, on-target operation within the laboratory. The selected candidate should possess excellent analytical, organizational and communication skills and be a self-starter willing to work efficiently and collaboratively in a dynamic environment. This role is primarily a laboratory position; contact with chemicals is part of the job. The role is fully onsite (5 days a week, 8-hour days) with occasional evening or weekend work required. The employee will be trained to use common lab equipment and minimize exposure to hazards. Desktop or laptop computer work is also a major component of the job. The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. While performing the duties of this job, the employee is occasionally exposed to work near moving mechanical parts; fumes or airborne particles; toxic or caustic chemicals; risk of electrical shock and vibration. The noise level in the work environment is usually moderate. The employee may frequently be required to sit and talk or hear. The employee is occasionally required to stand; walk; use hands to finger, handle, or feel; reach with hands and arms; climb or balance; stoop, knee crouch, or crawl and taste or smell. The employee must occasionally lift and/or move up to 25 pounds. Specific vision abilities in this job include close vision, depth perception and ability to adjust focus.


Primary Responsibilities/Accountabilities:

  • Primary responsibility is to support the Separations and Biophysics group within Analytical Sciences
  • Be a hands-on presence in the laboratory, supporting biophysical/ biochemical assay development and qualification using HPLC and CE (must have) for various modalities (preferably biologics). LC-MS (high-res) experience is also desirable.
  • Provide routine analytical characterization & testing support to partner groups including Upstream and Downstream PD, Formulations, and Research & Early Development (RED).
  • Document experimental results in the company electronic lab notebook (Benchling), author procedures, and contribute to technical documentation (test methods, development reports).
  • Actively participate in the operational aspects of the laboratory by conducting safety inspections, lab organization, ordering supplies, and performing routine equipment maintenance.
  • Present scientific literature and results from ongoing studies at group meetings and other discussion forums at the company.
  • Other duties as assigned.


Qualifications:

  • Bachelor's degree in Chemistry, Biochemistry, Analytical Chemistry, Chemical Engineering or a related field with 6+ years of experience in a Biologics or Pharmaceutical environment.
  • Master's degree in Chemistry, Biochemistry, Analytical Chemistry, Chemical Engineering or a related field with 4+ years of experience in a Biologics or Pharmaceutical environment.
  • Hands-on experience in the biotechnology industry or academic setting with a broad range of analytical techniques focused on analytical testing and characterization for proteins, peptides, and protein-conjugates is required.
  • Experience with biochemical characterization methods is required:
  • SEC, SCX, RP-HPLC experience is a must (Agilent/Waters/Thermo LC instruments)
  • Capillary Electrophoresis (PA800 or BioPhase8800) based methods (SDS for size separation, glycan profiling)
  • cIEF (Maurice) experience is highly desirable
  • LC-MS (Orbitrap/QToF/QQQ) method development experience also desirable
  • Technical understanding of all aspects of analytical testing, phase appropriate regulatory requirements, method qualifications, and method transfers.
  • Ability to independently troubleshoot issues, ideate, and develop insights into technical challenges and propose solutions to solve them.
  • Demonstrates attention-to-detail and "right-the-first time' approach
  • Excellent written and oral communication skills, with the ability to communicate complex information. Be able to present data/ideas to functional and cross-functional teams.
  • Ability to influence others effectively and develop collaborative relationships with partner teams.
  • Familiar with use of statistical software, electronic document management, and laboratory information management.
  • Ability to effectively analyze complex problems and present results effectively within and beyond the department
  • Ability to flexibly adapt to changing business needs and meet timelines.
  • Strong organizational skills with the ability to effectively multi-task and prioritize.


Preferred:

  • Experience in method development, qualification, and transfer to/from other laboratories, such as development and quality control.
  • Knowledge of biopharmaceutical process development is a plus.
  • Experience with automation is a plus.
  • Experience working in a cross-functional environment.
  • Good understanding of root cause analysis methodology.
Not Specified
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