Engineering Jobs in Pennsylvania

My lab is hiring a postdoc!

The Semantic Signals Lab at Carnegie Mellon University is looking for a postdoctoral researcher to join our team. By 2050, older adults will comprise 22% of the global population, placing greater demand on traditional healthcare systems. Meeting these challenges demand technical innovation at the interface of hardware, software, and intelligence. Our mission is to create scalable mobile systems for physiological intelligence using wireless sensing, signal processing, and AI. We invent bio- and physics-inspired hardware systems to decode hidden signals from the body and environment, and enable new sensory capabilities for millions of humans and machines.

Our innovations include using radar to contactlessly detect muscle fatigue and measure blood pressure, repurposing cheap earphone speakers to listen to heart valve mechanics, smartglasses that sense eye muscle signals to enable auto-focusing lenses for age-related vision loss, a smartphone attachment that isolates a speaker's voice in a noisy restaurant as assisitive listening aid, and transforming a standard tablet touchscreen into a sensor that can detect microliter-scale DNA samples.

Our work has been published in venues like SenSys, MobiSys, CHI, UIST, IROS, and Nature-family journals (Communications, Biomedical Engineering, Digital Medicine).

Pittsburgh is a great city, CMU is an amazing place to do research, and the lab has a collaborative, supportive culture. If this sounds like a fit, or if you know someone it might be a fit for, I'd love to hear from you. Feel free to DM me or email me at I will be at CHI 2026 and SenSys 2026 this year where our lab will be presenting full-length papers, feel free to come find me for a chat if you're interested.

More about our work:

Job Opportunity - Electrical Engineer

Location : New Freedom, PA

Duration : Long term

Position Summary

The Electrical Engineer will support product optimization initiatives through design analysis, component evaluation, simulation, and testing activities. This role involves reviewing existing product designs, identifying opportunities for component standardization, conducting simulations, and supporting testing and troubleshooting of electrical systems, including 3-phase systems. The ideal candidate is detail-oriented, technically sound, and eager to contribute in a collaborative engineering environment.

Key Responsibilities

• Research and analyze existing product designs to identify redundant components and recommend design optimizations.
• Review and analyze Bills of Materials (BOMs) to identify opportunities for component commonization and cost reduction.
• Interpret technical drawings, schematics, and electrical documentation accurately.
• Perform circuit simulations to evaluate the feasibility of component substitutions and validate design changes.
• Participate in testing and troubleshooting of 3-phase electrical systems, proactively identifying and resolving issues under the guidance of senior engineers.
• Utilize test equipment such as oscilloscopes, power analyzers, and related diagnostic tools.
• Maintain comprehensive documentation of design modifications, simulations, test procedures, and results.
• Collaborate with cross-functional teams to ensure design integrity and compliance with applicable standards.

Required Qualifications

• Bachelor’s degree in Electrical Engineering or a related discipline.
• Solid understanding of fundamental electrical engineering principles.
• Strong analytical skills with attention to detail.
• Ability to read and interpret technical drawings, schematics, and BOMs.
• Familiarity with electrical test equipment such as oscilloscopes and power analyzers.
• Knowledge of electrical components and systems.
• Strong communication and teamwork abilities.
• Willingness to learn and adapt in a fast-paced engineering environment.

Preferred Qualifications

• Hands-on experience in electrical testing and troubleshooting, including independent resolution of circuit- and system-level issues.
• Experience with circuit simulation tools such as SPICE or Saber.
• Familiarity with applicable industry standards and regulatory requirements.
• Exposure to 3-phase motors and related systems.

On behalf of a U.S.-based industrial solutions provider specializing in engineered mechanical systems and components for demanding applications, we are looking for a Purchasing Manager to lead strategic and operational purchasing activities.

Summary

• Location: Berwick, PA – onsite role
• Reports to: General Manager – Chief Purchasing Officer (dotted line)
• Scope: Strategic & Operational Procurement
• Cross-functional collaboration: Engineering, Production, Quality, Sales

Company

Our client is a growing industrial solutions provider with strong engineering capabilities and a solid reputation for quality, reliability, and customer focus. The company delivers customized mechanical systems and components for complex applications, supported by a robust and international supply chain. Continuous improvement, technical excellence, and long-term partnerships with customers and suppliers are core elements of the organization’s culture.

Position

This role is critical in supporting the company’s supply chain performance and overall business growth. The Purchasing Manager will ensure the best quality/price ratio, full compliance with technical specifications, and on-time delivery of components and raw materials. Working closely with Engineering, Production, Quality, and Project Management, the role offers both strategic responsibility and hands-on operational involvement.

Key Responsibilities

• Identify, qualify, and develop new suppliers at national and international level, continuously improving quality, service, and cost performance.
• Manage procurement of commercial and mechanical components, engineered-to-order parts, and metallic raw materials (steel, aluminum, special alloys).
• Monitor cost trends and market dynamics, proposing technical cost-saving initiatives.
• Align raw material market trends with purchased material costs through structured, contractual supplier agreements.
• Support and implement category strategies aligned with company and group objectives.
• Lead supplier negotiations, define commercial agreements and Service Level Agreements and establish corrective and improvement plans when required.
• Lead supplier negotiations, define commercial agreements and Service Level Agreements (SLAs), and establish corrective and improvement plans when required.
• Ensure recovery of costs related to non-quality issues or service failures.
• Guarantee timely and accurate communication between suppliers and internal stakeholders.
• Support purchasing budget definition and project costing activities in collaboration with Sales and Engineering.

Profile

• Degree in Engineering (Mechanical, Materials, or similar) or equivalent technical background.
• 5 years of experience as Buyer or Senior Buyer in an industrial environment, preferably within mechanical or metalworking industries.
• Strong understanding of technical drawings and mechanical manufacturing processes (turning, milling, treatments).
• Proven negotiation and supplier management experience, including international suppliers.
• Strong analytical, decision-making, and problem-solving skills.
• Authorization to work in the United Stateswithout visa sponsorship.

ARM Group LLC is looking for a self-driven and energetic Staff Engineer who is looking to grow and embodies an ownership mentality. The Staff Engineer will collaborate with a team of multi-disciplined engineers and scientists, project managers, CAD designers, and other staff to service our client’s needs. This role will support a wide range of projects related to our Energy & Power practice area in the areas of erosion and sediment control design, stormwater management design, and land development engineering.

The successful candidate will assist in performing engineering calculations, writing reports, and creating/updating design drawings using CAD and assist with client and regulator communications. This role may also support our solid waste management, environmental services, geotechnical engineering, oil and gas, water resources, and construction administration practice areas.

Location: This position can be filled in our Hershey, PA office.

Requirements

• Prepare, review, and update design drawings and investigation reports for commercial/industrial and utility scale solar projects throughout the Mid-Atlantic region.
• Observe and monitor field work to analyze possible problems.
• Perform and/or check technical calculations related to erosion and sediment control design, stormwater management design, and related land development engineering.
• Research code, zoning, ordinances, and other requirements as needed to ensure project compliance.
• Prepare reports, letters, emails, permit applications, etc. for projects.
• Collaborate with other team members to meet deliverables on project and obtain further knowledge and experiences.
• Effectively communicate with key stake holders including project manager, project engineers, and other members of the project team.
• Pro-actively recognize conditions and problems of non-routine nature, develop solutions, and seek guidance when needed.

Base Requirements:

• Bachelor's degree or equivalent in engineering (Civil or Environmental) from an accredited four-year college or university.
• Experience with Autodesk Civil 3D or equivalent engineering software.
• A self-starter possessing strong communication, planning and organizational skills.
• Desire to work on multiple projects in parallel rather than a single large project for months.
• Proficiency in Microsoft Office Suite.
• Requires travel to job sites and occasionally out of the local area overnight stay.
• Valid drivers license

Preferred Requirements:

• E.I.T. certification preferred, but the opportunity to obtain certification can be developed.

Your Wellness, Our Priority: A Look at Our Benefits

We invest in our team's well-being and future through a comprehensive benefits package with a range of offerings designed to support you holistically. Our health and wellness offerings include two Health Insurance options (Traditional PPO and QHDHP with an HSA), vision and dental coverage, life insurance, disability protection, accident and critical illness coverage. To enhance your future financial security, we provide a 401(k) with company match, HSA/FSA accounts, and 529 college savings plans. Work-life balance is prioritized through our generous PTO starting at 15 days per year and 10 paid holidays per year, giving you ample time to rest, recharge, and attend to life outside the office. An Employee Assistance Program is provided to you and your household with resources to assist you in managing a variety of situations. We invest in your professional growth through our Tuition Reimbursement program and continuing education opportunities. After 6 months of employment, all team members become eligible for quarterly bonuses, providing additional avenues for financial growth. This robust package is designed to foster a workplace where you can thrive both personally and professionally, underscoring our dedication to your overall well-being and future success.

Project Manager

Carr & Duff, LLC has been a leading electrical contractor in the Greater Philadelphia Tri-State Area and Mid Atlantic Region since 1958. With over 65 years of experience, C&D has earned a reputation for excellence in tackling complex electrical construction projects with a focus on safety, quality, and timeliness. We now offer services beyond the Mid-Atlantic regions to customers all along the East Coast.

Why Work Here

Carr & Duff is a growing diverse company that rewards hard work and dedication, and we invest time and resources into providing professional development and career growth opportunities. We need top of the line team members who genuinely care about the customer and the quality of the work they produce. C&D seeks to develop strong relationships with preferred customers, and most importantly, we operate as a team

Position Overview:

A Project Manager provides project leadership for small, medium and large electrical construction projects throughout the region. This position is accountable for all aspects of a project's success from initial estimating, bidding process, review of engineering plans and meeting or exceeding the clients' expectations through profitable completion of the job. Additionally, the P/M collaborates with other functional project teams in the planning and execution of the job. This includes:

• Contract interpretation/dispute resolution.
• Assessing and recommending project resource requirements.
• Managing electrical projects.
• Estimating.
• Interfacing with client representatives regarding the project's progress.
• Management of project controls and accounting.
• Training, mentoring and coaching Assistant Project Managers.
• Ensure field engineering activities comply with company and contract requirements and support overall construction schedule.
• Provide technical support for construction, including participation in construction planning.
• Coordinate with the engineering group to assure completeness and correctness of design and construction documents. Plan, conduct, and monitor work in accordance with engineering construction plans and specifications.

This position is part of the company's Project Management Team and is considered strategic within the organization. The position will report to the company's office in Huntingdon Valley, PA and could include both long and short term remote field assignments, as determined by specified projects and the location of those projects.

Major Job Elements:

• Manages overall project performance (safety, quality, scope, schedule, innovation, cost, communication, resource issues, risks and customer satisfaction).
• Serves as single point-of-contact by establishing, maintaining and managing customer, subcontractor, and joint venture partner's expectations (where applicable) relating to project performance.
• Reports project status and performance data as required to management.
• Ensures strict adherence to all Safety Policies, Procedures and Practices.
• Plans, monitors, and controls the project throughout its life-cycle (Estimating, bid, contract award, engineering/design, procurement, and construction close out).
• At any given time could be involved in combinations of:
• Managing a major project from $1 to $10 million or a portfolio of smaller projects from $100k to $999k with durations from several weeks to several years.
• Mentoring others.
• Assist in marketing and business development activities as required.
• Acts as sponsor to ensure large projects are meeting expectations (safety, cost, schedule etc.)

DISCLAIMER FOR RECRUITMENT AGENCIES

Carr & Duff does not accept unsolicited CVs from recruiters or employment agencies in response to the Carr & Duff job Careers page, social media post, or any other speculative applications not related to a specific job posting. Carr & Duff will not consider or agree to payment of any referral compensation or recruiter fee relating to these unsolicited CVs.

Carr & Duff explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruiter or agency.

Carr & Duff operates an Applicant Tracking System (ATS), any unsolicited CVs, including those submitted to hiring managers, are deemed to be provided without any engagement/obligation on the side of Carr & Duff. Any CVs not submitted via the ATS, including any CVs sent via email, will be deemed unsolicited.

SENIOR TRANSPORTATION PLANNER   

The Lehigh Valley Planning Commission (LVPC), in coordination with the Lehigh Valley Transportation Study (LVTS), is seeking a Senior Transportation Planner to lead regional transportation planning initiatives across the Lehigh Valley. This position plays a key role in shaping future infrastructure investments through sound planning, data analysis, and interagency coordination.  

As a senior member of the Transportation Planning + Data Division, the selected candidate will independently manage complex transportation projects that intersect with land use, safety, system performance, freight, active transportation, and infrastructure management. The role combines technical knowledge with collaborative leadership to support the region’s evolving transportation needs and priorities.  

This position serves as a trusted resource to internal teams and external stakeholders, including state and federal transportation agencies, local governments, and the public.  

ESSENTIAL DUTIES + RESPONSIBILITIES  

Working under the general direction of the Director of Transportation, the Senior Transportation Planner:  

• Lead the development and implementation of the Metropolitan Transportation Plan (MTP) and supporting documents.  
• Oversee the Transportation Improvement Program (TIP) and coordinate with state partners on the Statewide Transportation Improvement Program (STIP).  
• Support planning initiatives that address safety, mobility, system condition, freight movement, and multimodal accessibility.  
• Manage transportation funding programs, including review of federal and state grant opportunities and support materials.  
• Analyze system performance using a variety of data sources and tools, including GIS, travel demand models, and other technical platforms.  
• Integrate transportation and land use policy by reviewing development proposals, local plans, and ordinances for potential impacts on the regional network.  
• Prepare and present clear, concise reports and briefings to technical and non-technical audiences, including elected officials and community groups.  
• Engage with diverse community stakeholders and support inclusive public involvement strategies.  
• Collaborate with state, federal, and local partners, including PennDOT District 5-0, FHWA, FTA, and municipal governments.  
• Represent the LVPC/LVTS in regional, statewide, and national working groups focused on areas such as freight, transit, trails, traffic operations, and infrastructure planning.  
• Participate in and support transportation-related advisory committees, public meetings, and planning forums.  
• Other duties as assigned.  

KNOWLEDGE, SKILLS + ABILITIES  

• Comprehensive understanding of transportation planning principles and best practices.  
• Ability to manage multiple tasks and projects with minimal supervision.  
• Effective team collaborator who can also lead independent workstreams.  
• Familiarity with public engagement practices and ability to communicate with a wide range of audiences.  
• Proficient in Microsoft Office 365, Microsoft Teams, and standard communication tools.  
• Ability to interpret technical data and convert it into accessible, actionable planning materials.  

QUALIFICATIONS AND REQUIREMENTS:  

Minimum Requirements:  

• Bachelor's degree in Urban Planning, Transportation Planning, Civil Engineering, or a closely related field.  
• Minimum of 5 years of professional experience in transportation or regional planning.  
• Proven ability to manage projects and lead multi-agency planning efforts.  
• Strong verbal, written, and graphical communication skills.  

 Preferred Qualifications:  

• Master's degree or equivalent experience.  
• Certification with the American Institute of Certified Planners (AICP), or willingness to pursue certification.  
• Experience with GIS platforms and tools (ArcGIS Pro, StoryMaps, etc.).  
• Familiarity with travel demand models, REMI, or other forecasting tools.  
• Knowledge of PennDOT Connects, the PennDOT One Map system, and current state/federal transportation planning requirements.  
• Understanding of funding programs and related transportation initiatives.  

  Other Requirements  

• This position requires participation at some early morning, evening and weekend meetings and events. Valid driver’s license is also, required within six months of employment.  

SALARY + BENEFITS   

• Grade 10 - $77,506 – $112,383 per annum; excellent benefits.  
• The Lehigh Valley Planning Commission also, budgets for training and professional membership(s). The LVPC is active in the American Planning Association (national, state and regional,) American Association of Metropolitan Planning Organizations, National Association of Regional Councils, Urban Land Institute, Green Building United/US Green Building Council, Lincoln Institute of Land Policy, ESRI, REMI, Greater Lehigh Valley Chamber of Commerce, among other local, regional, state and national allied organizations and initiatives. Team members are encouraged to participate with partner entities.  

APPLY  

Only e-mail submissions to will be accepted and must include:  

1. Current resume detailing your education and experience.  
2. Letter of interest describing how you meet the qualifications for this position and why you would like to be considered. Please address this letter to, Becky Bradley, AICP, Executive Director, Lehigh Valley Planning Commission, 615 Waterfront Drive, Suite 201, Allentown, PA 18102.  
3. Work samples or links to work that demonstrate your capabilities.  
4. Minimum of three (3) professional references with contact information.  

Position open until filled. Review of applications and interviews will begin immediately.  

TEAM COMMITMENT  

The Lehigh Valley Planning Commission provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, age, disability, or genetics. In addition to federal law requirements, the Lehigh Valley Planning Commission complies with applicable state and local laws governing nondiscrimination in employment. This policy applies to all terms and conditions of employment.  

In Compliance with the Immigration Reform and Control Act of 1986, applicants hired by LVPC must show acceptable proof of identity and evidence of authorization to work in the United States. Perrsons with a disability who need assistance with their application or that need this announcement in an alternative format may call (61  

FURTHER INFORMATION  

Visit   for more information on the Lehigh Valley Planning Commission, our work program, products and services.  

Software Engineer (Backend/APIs)

Software Engineers- bring your experience to work for you where people love to shop! Boscov's is a chain of full service department stores serving the total family needs of our customers. For over 100 years, Boscov's has been known for its great values and famous brands, and for offering a broad selection of quality merchandise in its stores and online.

We're looking for a backend engineer with a few years of experience who's ready to grow. This role will maintain and improve the systems that power a 100+ year old retail company — writing clean code, learning from senior engineers, and shipping features that matter. The ideal candidate is prepared to contribute meaningfully, receive constructive feedback, and develop professionally.

Job Responsibilities:

• Build and maintain backend systems and APIs in C# / .NET with SQL
• Implement features across our applications
• Collaborate with the team to uphold engineering standards, including testing, code reviews, and clean architecture
• Learn from senior engineers and team members
• Contribute to frontend work as needed (this is not a full-stack role, though comfort with HTML/CSS/JS is expected)
• Actively seek feedback and pursue continuous professional development

Qualifications:

• Approximately 3 years of software development experience
• C# / .NET expertise as a primary development platform
• SQL basics, including writing queries, understanding joins, and troubleshooting data issues
• Demonstrated desire for feedback and a commitment to continuous improvement
• Intellectual curiosity and a propensity to question and understand underlying systems

Preferred Qualifications

• Experience with REST API design
• Familiarity with testing (unit tests, integration tests)
• Exposure to CI/CD
• Any experience with retail or enterprise systems

Benefits

At Boscov's, we value our employees, and that's why we provide a competitive compensation and benefits package. As a Full-Time member of our team, you will be eligible to receive:

• Comprehensive benefits package, including medical/dental/vision
• Short term disability/ Long term disability- voluntary
• Life Insurance (company paid)
• 401(k) w/ company match
• Weekly Pay
• Paid vacation
• Liberal employee discount

Work where people love to shop!

Equal Opportunity Employer

Anotech, an Alten group company, specializes in engineering consulting for the energy, infrastructure and process industries. Present in 40 countries, we offer reliable and efficient support to our clients in the realization of their large-scale projects, while maintaining compliance with local and international regulations, by presenting them to the highest qualified industry talent. Our goal is to deliver tailor-made engineering services to major industry projects that will shape tomorrow.

Our team is currently looking for a Cost Controller for a critical greenfield construction project. This role is responsible for managing and overseeing cost control processes across a new drug production facility to provide actionable insights to stakeholders and support informed project decision making.

About you:

• Bachelor’s degree in Finance, Accounting, Business Administration, or a related field (Master’s degree or professional certifications such as CPA, CMA, or ACCA are a plus).
• Proven experience in cost control, financial analysis, or project management, with 5-7 years in a leadership role.
• Strong knowledge of cost management principles, budgeting, forecasting, and financial reporting.
• Expertise in financial software (e.g., SAP, Oracle, or similar tools) and advanced proficiency in Microsoft Excel.
• Strong preference for candidates with background in pharma, bio-tech, or nuclear industries
• Exceptional analytical and problem-solving skills, with an ability to interpret complex data and provide actionable insights.
• Strong leadership and team management abilities, with a track record of driving results through collaboration.
• Excellent communication and presentation skills, with the ability to convey financial concepts to non-finance stakeholders.
• Proactive and detail-oriented, with an ability to manage multiple priorities in a fast-paced environment.

About the role:

• Cost Management and oversight, including developing and implementing cost control plans and processes
• Monitor and analyze project budgets, expenditures and forecasts
• Identify cost saving opportunities, risks and variances
• Prepare cost reports based on dashboards, conducting financial analysis insights to leadership and stakeholders
• Work closely with project managers, engineering teams, procurement teams and finance tems to ensure cost control practices

Due to business need, all candidates must be local to the area and have valid US work authorization. Sponsorship will not be offered at this time.

Ainsley Search Group is hiring a Plant Engineering Manager with solid experience in plant engineering and maintenance management for a High Growth Manufacturer located in Chester County. This Plant Engineering Manager will report to VP of Operations, lead and develop a maintenance and engineering team and plan, optimize PM, optimize plant reliability and equipment performance output, further promote plant safety, and reliability, oversee the life cycle of major plant engineering projects. This is a full-time, permanent opportunity with lucrative compensation, bonus, benefit and growth.

Responsibilities:

• Lead, manage, mentor, and develop a plant engineering team, plan staffing outlook for maintenance and engineering team based on operational demand and make decision on hiring, training, etc.
• Report to VP of Operations and collaborate with cross functional teams to develop and implement a facility maintenance system, drive PM, reliability, process improvement on safety.
• Lead life cycle of major plant expansion, capital projects, oversee plant engineering projects design, execution, commissioning, close-out, manage contractor, equipment manufacturer, suppliers’ quality, performance and support contractor and supplier selection and qualification process.
• Develop, implement, and standardize maintenance practice, procedure and process across organization, plan and optimize resource for predictive and preventive maintenance, lead and manage plant maintenance programs, oversee equipment inspections, support safety and reliability training to optimize overall plant safety, reliability, and efficiency.
• Manage budget, cost and budget planning for all plant engineering projects, maintenance programs, identify area of cost saving opportunities and drive cost saving initiatives.
• Lead the security, sanitation, janitorial, utility, and property management programs across plant, create and maintain master site plan and collaborate with safety and EHS to ensure compliance with OSHA, GMP and EHS regulations.
• Collect, analyze maintenance data, KPI and operational data to track, monitor up-time, down-time performance on plant systems such as chiller, HVAC, condensate systems, plant steamer, etc, identify root causes and opportunities of improvement, further achieve higher efficiency, accuracy, cost saving on equipment performance output.
• Collaborate with EHS, Reliability Engineer, Project Engineer to support new capex investment, installation, commissioning, upgrade, routine maintenance, repair, and upgrade.
• Collaborate with Process, Quality, Reliability engineering and senior management, based on operational data, analysis to support CI, sustain and promote process safety, equipment reliability, and optimize operational output.
• Collaborate with executive management team on strategic planning regarding plant expansion, major capex investment, maintenance program, etc.
• Lead the new plant site design, development projects from start to finish, develop and modify new plant layout and expanded layout for existing plant facility.

Qualifications:

• Bachelor’s Degree in technical degree is a plus, higher education desired.
• Recent years of tenure as a hands-on senior leader as Plant Engineering Manager, or related roles within manufacturing industry, expose to high yield, fast speed automated manufacturing environment required.
• Hands-on leadership skill, ability to establish rapport and hold subordinates accountable, ability to restructure and develop a team.
• Strong analytical and problem-solving skill, strong knowledge in Project Management skill.
• Strong mindset in process improvement, process safety and reliability, ability to make difficult decision independently.
• Proficient in Microsoft Suite, CMMS and ERP based systems.
• Aspiration to advance to senior management level

Compensation and Benefit:

• Lucrative compensation
• Yearend bonus
• 401k with match
• PTO
• Paid Holidays
• Health, dental and vision
• Life Insurance
• Disability Insurance
• Tuition Reimbursement
• Relocation Assistance

Job Title: Post-Doctoral Scientist, Nucleic Acid Chemistry

Location: Philadelphia

Reports To: Director, Nucleic Acid Chemistry

Type: Full-Time

Company Overview:

Based in Philadelphia, Aro Biotherapeutics is a clinical stage biotechnology company dedicated to advancing transformative therapies in Inflammation and Immunological Disorders (I&I). Leveraging cutting-edge RNA technologies including siRNA, we are building a pipeline of innovative treatments designed to address unmet patient needs in I&I, while advancing products in other therapeutic areas in collaboration with partners.

Position Summary:

Aro is expanding our Nucleic Acids Chemistry team to design and synthesize novel Centyrin-oligonucleotide conjugate based therapeutics. The focus of this role would be on improving potency, reducing OTEs and creating new IP for Aro’s siRNA design. The ideal candidate will have a good understanding of how to generate novel and testable oligonucleotide designs to contribute to oligonucleotide-based therapeutic discovery. The position will require hands-on laboratory work. Close collaboration with other members of the Aro team across protein engineering, chemistry and biology is essential. In this role, you will have the opportunity to contribute directly to efforts that support the company’s portfolio of preclinical therapeutic candidates.

Key Responsibilities:

• Perform oligonucleotide synthesis from low milligram to gram scale
• Develop and execute clear synthetic strategies towards chemically modified oligonucleotides using state-of-the-art synthetic methodologies
• Optimize existing oligonucleotide synthetic protocols, purification, and analytical methods
• Troubleshoot oligo synthesis issues, maintain lab equipment (Mermade, LCMS, HPLC etc.) and conduct safe lab operations
• HPLC purification and LCMS analysis of synthesized siRNAs and other oligonucleotides
• Maintain up to date, high quality electronic lab notebooks, and quality CoAs
• Regularly present work to internal project teams and R&D Leadership
• Comply with laboratory safety procedures and company guidelines

Qualifications:

• PhD in Chemistry required
• Perform oligonucleotide synthesis from low milligram to gram scale
• Develop and execute clear synthetic strategies towards chemically modified oligonucleotides using state-of-the-art synthetic methodologies
• Optimize existing oligonucleotide synthetic protocols, purification, and analytical methods
• Troubleshoot oligo synthesis issues, maintain lab equipment (Mermade, LCMS, HPLC etc.) and conduct safe lab operations
• HPLC purification and LCMS analysis of synthesized siRNAs and other oligonucleotides
• Maintain up to date, high quality electronic lab notebooks, and quality CoAs
• Regularly present work to internal project teams and R&D Leadership
• Comply with laboratory safety procedures and company guidelines

Equal Opportunity Employer Disclaimer:

Aro Biotherapeutics is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All employment decisions are based on qualifications, merit, and business needs. We do not discriminate on the basis of race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or any other characteristic protected under applicable law.

Employment at Will Disclaimer:

Nothing in this job description is intended to create an employment contract. Employment with Aro Biotherapeutics is at-will and may be terminated by either the employee or the company at any time, with or without cause or notice.