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My lab is hiring a postdoc!

The Semantic Signals Lab at Carnegie Mellon University is looking for a postdoctoral researcher to join our team. By 2050, older adults will comprise 22% of the global population, placing greater demand on traditional healthcare systems. Meeting these challenges demand technical innovation at the interface of hardware, software, and intelligence. Our mission is to create scalable mobile systems for physiological intelligence using wireless sensing, signal processing, and AI. We invent bio- and physics-inspired hardware systems to decode hidden signals from the body and environment, and enable new sensory capabilities for millions of humans and machines.

Our innovations include using radar to contactlessly detect muscle fatigue and measure blood pressure, repurposing cheap earphone speakers to listen to heart valve mechanics, smartglasses that sense eye muscle signals to enable auto-focusing lenses for age-related vision loss, a smartphone attachment that isolates a speaker's voice in a noisy restaurant as assisitive listening aid, and transforming a standard tablet touchscreen into a sensor that can detect microliter-scale DNA samples.

Our work has been published in venues like SenSys, MobiSys, CHI, UIST, IROS, and Nature-family journals (Communications, Biomedical Engineering, Digital Medicine).

Pittsburgh is a great city, CMU is an amazing place to do research, and the lab has a collaborative, supportive culture. If this sounds like a fit, or if you know someone it might be a fit for, I'd love to hear from you. Feel free to DM me or email me at I will be at CHI 2026 and SenSys 2026 this year where our lab will be presenting full-length papers, feel free to come find me for a chat if you're interested.

More about our work:

Job Title: Post-Doctoral Scientist, Nucleic Acid Chemistry

Location: Philadelphia

Reports To: Director, Nucleic Acid Chemistry

Type: Full-Time

Company Overview:

Based in Philadelphia, Aro Biotherapeutics is a clinical stage biotechnology company dedicated to advancing transformative therapies in Inflammation and Immunological Disorders (I&I). Leveraging cutting-edge RNA technologies including siRNA, we are building a pipeline of innovative treatments designed to address unmet patient needs in I&I, while advancing products in other therapeutic areas in collaboration with partners.

Position Summary:

Aro is expanding our Nucleic Acids Chemistry team to design and synthesize novel Centyrin-oligonucleotide conjugate based therapeutics. The focus of this role would be on improving potency, reducing OTEs and creating new IP for Aro’s siRNA design. The ideal candidate will have a good understanding of how to generate novel and testable oligonucleotide designs to contribute to oligonucleotide-based therapeutic discovery. The position will require hands-on laboratory work. Close collaboration with other members of the Aro team across protein engineering, chemistry and biology is essential. In this role, you will have the opportunity to contribute directly to efforts that support the company’s portfolio of preclinical therapeutic candidates.

Key Responsibilities:

• Perform oligonucleotide synthesis from low milligram to gram scale
• Develop and execute clear synthetic strategies towards chemically modified oligonucleotides using state-of-the-art synthetic methodologies
• Optimize existing oligonucleotide synthetic protocols, purification, and analytical methods
• Troubleshoot oligo synthesis issues, maintain lab equipment (Mermade, LCMS, HPLC etc.) and conduct safe lab operations
• HPLC purification and LCMS analysis of synthesized siRNAs and other oligonucleotides
• Maintain up to date, high quality electronic lab notebooks, and quality CoAs
• Regularly present work to internal project teams and R&D Leadership
• Comply with laboratory safety procedures and company guidelines

Qualifications:

• PhD in Chemistry required
• Perform oligonucleotide synthesis from low milligram to gram scale
• Develop and execute clear synthetic strategies towards chemically modified oligonucleotides using state-of-the-art synthetic methodologies
• Optimize existing oligonucleotide synthetic protocols, purification, and analytical methods
• Troubleshoot oligo synthesis issues, maintain lab equipment (Mermade, LCMS, HPLC etc.) and conduct safe lab operations
• HPLC purification and LCMS analysis of synthesized siRNAs and other oligonucleotides
• Maintain up to date, high quality electronic lab notebooks, and quality CoAs
• Regularly present work to internal project teams and R&D Leadership
• Comply with laboratory safety procedures and company guidelines

Equal Opportunity Employer Disclaimer:

Aro Biotherapeutics is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All employment decisions are based on qualifications, merit, and business needs. We do not discriminate on the basis of race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or any other characteristic protected under applicable law.

Employment at Will Disclaimer:

Nothing in this job description is intended to create an employment contract. Employment with Aro Biotherapeutics is at-will and may be terminated by either the employee or the company at any time, with or without cause or notice.