Agonist Vs Antagonist Jobs in Usa

The Department of Pharmacology and Neuroscience, Creighton University School of Medicine in Omaha, NE, is seeking a postdoctoral fellow for a project funded by NIH.

Key Responsibilities

Airway hyperresponsiveness andairway inflammation are hallmarks of asthma that is clinically managed with 2-agonist bronchodilatorsand inhaled corticosteroids. Refractory asthma manifests with persistent symptoms despite the use of high-dose oral corticosteroids and long-acting 2-agonists and poses a major healthcare challenge. Understanding the molecular mechanisms of therapeutic resistance and developing strategies to overcome such resistance poses a significant unmet need.

We are seeking a talented, highly motivated individual who is broadly interested in the molecular and cellular basis of refractory asthma. Our research focuses on understanding the molecular mechanisms of therapeutic resistance and developing new strategies to overcome such resistance inrefractory asthma.

An ideal candidate will be expected to develop the project independently and will also have the opportunity to interact and participate in other studies of our multidisciplinary group in the lab and throughout the department. Our research team highly values creativity and independence in a collaborative and collegial academic environment.

A successful candidate will have a doctorate in areas related to cell and molecular biology, immunology, signal transduction, and asthma supported by strong publications. Prior experience in airway smooth muscle cells and mouse models of asthma would be advantageous.

The candidate will also be asked to assist in training of laboratory staff and graduate students in research techniques as well as writing grant proposals. This is a full time, grant funded role.

Qualifications

• 
  
• Applicants should have a Ph.D., M.D., or M.D./Ph.D. degree
  
• One year of related experience
  
• Significant research accomplishments and scholarly promise
  

How to Apply: Include the below 3 items to application for consideration.

1. 
   
2. Curriculum vitae
   
3. A brief summary of research to date and preferred research directions for the next few years
   
4. Names of three referees who can write letters of recommendation (at least one outside the applicant's home institution)
   

Creighton University is a private research university in Omaha, Nebraska, USA. Founded in 1878, its ranking in the 2022-2023 edition of Best Colleges is #115 of National Universities, and #90 in Best Value Schools in USA.

AAP/EEO Statement:
Creighton University is committed to providing a safe and non-discriminatory educational and employment environment. The University admits qualified students, hires qualified employees and accepts patients for treatment without regard to race, color, religion, sex, marital status, national origin, age, disability, citizenship, sexual orientation, gender identity, gender expression, veteran status, or other status protected by law. Its education and employment policies, scholarship and loan programs, and other programs and activities, are administered without unlawful discrimination.

Disclosure Statement:
This description describes the general nature of work to be performed and does not include an exhaustive list of all duties, skills, or abilities required. Regular, reliable attendance is an essential function and all employees are required to follow any other job-related instructions and to perform any other job-related duties as requested by their supervisor. Employees may also be required to work in excess of normal working hours as workloads and seasonal activities necessitate. A complete description is available in the Human Resource office located at 3006 Webster Street Omaha, NE. Creighton University reserves the right to modify duties, responsibilities and activities at any time with or without notice.

Position Summary:

We are seeking a highly motivated attorney to join our legal team as Corporate Counsel/Sr. Corporate Counsel. This role will support the company’s public company reporting obligations, corporate governance processes, compliance initiatives, and contracting activities across the organization. Title and level will be determined based on experience and scope of responsibility.

This position is well-suited for a life sciences attorney who thrives in a fast-paced, clinical-stage biotech environment and enjoys partnering with cross-functional teams to provide practical legal guidance. The role requires strong attention to detail, sound judgment, and the ability to manage a broad range of legal matters in a growing organization.

The successful candidate will work closely with the General Counsel and senior leadership, partnering with teams across Finance, Investor Relations, Clinical Development, Regulatory, Technical Operations, and HR, and coordinating with external counsel as needed.

Key Responsibilities:

Securities & Corporate Governance

• Assist in the preparation and review of SEC filings, including Forms 10-K, 10-Q, 8-K, proxy statements, and Section 16 filings.
• Partner with Finance and Investor Relations to support the company’s disclosure processes, planning and drafting, including for earnings releases, investor presentations, and proxy materials.
• Monitor and advise on securities law compliance, including Nasdaq listing standards, Sarbanes-Oxley requirements, and insider trading policies.
• Provide legal support for capital markets transactions, including equity offerings and financings common in clinical-stage biotech companies.
• Support Board of Directors and committee governance activities, including preparation of board materials and maintenance of governance documentation.
• Provide legal guidance on corporate governance and regulatory requirements affecting the organization.
• Partner with HR and leadership on matters including equity plans and corporate policies.

Healthcare, Data Privacy, and Corporate Compliance

• Serve as a trusted advisor to senior leadership and cross-functional teams on business and compliance strategies, establishing the Compliance function as an approachable, knowledgeable, practical, and solutions-oriented business partner.
• Assist with the development and maintenance of policies and procedures to support the company’s corporate governance initiatives, healthcare compliance programs, and privacy framework, including the company’s code of business conduct and ethics.
• Serve as the go-to internal lead for guidance concerning compliance-related regulations, including data protection, information security, GDPR, and HIPAA, and monitor changes in healthcare compliance and data protection requirements to operationalize “fit for purpose” program updates.
• Coordinate and support the company’s privacy program activities, including Data Protection Impact Assessments (DPIAs), Records of Processing Activities (RoPAs), data mapping, maintenance of related documentation, and facilitation of data subject requests.
• Lead risk assessments to identify and prioritize compliance-related risks.
• Develop and deliver risk-based compliance training and guidance materials for employees across the company.
• Partner with the company’s Information Technology team to mitigate information security-related risks, including risks related to AI adoption, privacy matters, and cybersecurity incidents.

Contracting Matters

• Draft, review, and negotiate a wide range of life sciences agreements, including:
• Clinical trial agreements
• CRO and vendor agreements
• Manufacturing and supply agreements
• Licensing and collaboration agreements
• Research and development agreements
• Technology and services agreements
• Serve as a legal partner to cross-functional teams including Clinical Development, Regulatory, Technical Operations, R&D, and G&A functions.
• Support negotiation of complex and high-impact agreements, liaise with our clinical research organizations (CROs) to manage all aspects of contracting processes for large scale clinical trials, and escalate strategic matters as appropriate.
• Contribute to the development of contract templates, playbooks, and contracting best practices to improve efficiency and consistency.

Cross-Functional Legal Support

• Partner with the General Counsel and legal team on a variety of matters affecting the organization.
• Provide legal support on issues arising throughout the drug development lifecycle, including regulatory, operational, and compliance considerations.
• Coordinate with external counsel and internal stakeholders to support key legal initiatives and transactions.
• Contribute to a collaborative, business-oriented legal function that supports the company’s mission and growth.

Qualifications:

• J.D. from an accredited law school and admission to practice in at least one U.S. jurisdiction.
• 6+ years of legal experience, including corporate securities, compliance, and/or commercial contracting experience at a top law firm and/or public life sciences company.
• Strong knowledge of SEC regulations, Sarbanes-Oxley, public company disclosure requirements, and stock exchange listing standards.
• Experience drafting and negotiating complex life sciences or other agreements, particularly those supporting clinical development and technical operations.
• Understanding of drug development lifecycle and regulatory environment impacting biotechnology companies.
• Excellent analytical, communication, and stakeholder management skills.
• Ability to manage multiple priorities, make decisions with incomplete information, and operate effectively in a fast-paced, collaborative environment.

Preferred Experience:

• Experience supporting a clinical-stage biotechnology or pharmaceutical company.
• Familiarity with clinical development operations, CRO agreements, manufacturing agreements, and licensing transactions.
• Experience supporting public company reporting and governance processes.
• Experience working in a lean legal team environment with exposure to a broad range of legal matters.
• Demonstrated project management skills, including successful execution of complex projects with multiple stakeholders and utilization of soft skills to maximize team collaboration and effectiveness.

About Upstream Bio:

Upstream Bio is a public company based in Waltham, MA. We are developing verekitug, the only known antagonist currently in development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP). We have advanced this highly potent monoclonal antibody into separate Phase 2 trials for the treatment of severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD). Our experienced team is committed to maximizing verekitug’s unique attributes to address the substantial unmet needs for patients underserved by today’s standard of care. Learn more about us at .

Compensation

Target Salary Range: $234,000 -$286,000

*Base Compensation for this role will depend on a number of factors including a candidate’s qualifications, skills, competencies, and experience. Base pay is only one component of the company’s total rewards package. All regular employees are also eligible for the company’s cash bonus and equity incentive programs. Additional benefits include health care, vision, dental, retirement, PTO, etc.

Position Summary:

The Associate Director, Quality Control will be responsible for providing strategic, scientific, and operational leadership for the development, qualification, validation, and lifecycle management of analytical methods supporting Upstream Bio’s lead program verekitug. This role will manage and execute GMP quality control (QC) activities directly related to batch release for clinical trial material supply. The leader in this role must assure that quality controls for investigational new drugs (investigational medicinal products) meet all quality requirements, regulatory standards, and meet continuous clinical supply and delivery expectations. The Associate Director will report to Senior Director of Analytical and serve as a key partner to Quality, CMC, Regulatory, and cross-functional teams. This individual will provide technical guidance and business acumen to ensure execution of analytical activities for late-stage programs through BLA/MAA submission, approval, and commercial launch.

Key Responsibilities:

• Author, review and approve analytical method procedures/SOPs
• Author, review and approve analytical method transfer/qualification/validation protocols and reports
• Manage external CDMOs and CROs to execute Development and GMP release and stability testing of Drug Substance and Drug Product in a compliant-manner
• Establish and manage reference standard and critical reagent programs
• Participate in the laboratory quality system activities such as internal audits, writing standard operating procedures, and documentation review.
• Perform data verification and audits in order to ensure accuracy of data and analytical processes.
• Ensure compliance with company policies and SOPs as well as global health authority guidelines.
• Create, analyze, verify, and approve QC data such as method validation, release and stability, results, reports, and Certificates of Analysis (COAs).
• Generate, review, and revise specifications, SOPs, and other QC laboratory and testing documentation.
• Lead Out-of-Specification (OOS), Out-of-Trend (OOT), and Deviation investigations related to the QC laboratory and ensure effective corrective and preventive actions (CAPAs) are implemented.

Qualifications:

• Experience in stability study performance/evaluation and/or knowledge/familiarity with USP/compendial testing is helpful.
• Excellent verbal and written communication/interpersonal skills, problem-solving skills, organizational skills, and the ability to work in a diverse team environment are essential.
• Proficiency with Microsoft software (Word / EXCEL / PowerPoint), Stability software and statistical analysis/trending to support shelf life and labeling is expected.

Knowledge and skills (general and technical) preferred:

• Broad background, strong comprehension, and demonstrated skills in analytical methods development/validation/transfer/similar, reference standards characterization/structural elucidation, and unknown identification.

Education level and/or relevant experience required:

• Bachelor’s degree in a scientific or allied health field (or equivalent degree) and 10+ years of demonstrated success in leading cross-functional teams and managing projects along with 7+ years relevant analytical experience in a cGMP-compliant pharmaceutical laboratory environment. Any ASQ or other certifications is a plus.

About Upstream Bio:

Upstream Bio is a public company based in Waltham, MA. We are developing verekitug, the only known antagonist currently in development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP). We have advanced this highly potent monoclonal antibody into separate Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and plan to initiate development in chronic obstructive pulmonary disease (COPD). Our experienced team is committed to maximizing verekitug’s unique attributes to address the substantial unmet needs for patients underserved by today’s standard of care. Learn more about us at .

Compensation

Target Salary Range: $176,400 - $215,600

*Base Compensation for this role will depend on a number of factors including a candidate’s qualifications, skills, competencies, and experience. Base pay is only one component of the company’s total rewards package. All regular employees are also eligible for the corporate bonus program or the incentive compensation program (if applicable), as well as equity. Additional benefits include health care, vision, dental, retirement, PTO, etc.

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. By targeting this clinically proven therapeutic target with novel, oral small molecules, the Pharvaris team is advancing new alternatives to injected therapies for the prevention and treatment of hereditary angioedema (HAE) attacks, and other bradykinin B2-receptor-mediated indications. HAE is a rare and potentially life-threatening genetic disease and people living with HAE can suffer sudden and prolonged attacks of swelling in multiple areas of the body, including the airway, which can be life-threatening.

We are expanding our U.S. Medical Affairs team and are looking for a Medical Science Liaison to join our team and report to our Head of MSLs North America

We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely.

Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives. If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you!

Location

This is a field based medical affairs role

Responsibilities:

• Serve as the field-based extension of the Pharvaris’ Medical Affairs Team
• Field-based activities expected to comprise >80% of MSL responsibilities.
• Systematically identify the scientific exchange needs of Key Opinion Leaders (KOLs), investigators and other stakeholders in patient care, establish strong professional relationships, provide credible scientific expertise and serve as a liaison to Pharvaris North America’s Medical, Clinical Development/Operations and external partners.
• Ensure compliant communication and education of Pharvaris’ product portfolio to meet the educational and professional needs of Pharvaris’ key customers.
• Responds effectively to requests for scientific exchange.
• Support design and implementation of scientific programs with external experts and Global Medical Affairs
• Support local team disease area and product knowledge through scientific training.
• Maintain personal expertise in relevant disease areas and MSL best practices

KOL/HCP Relationship Management:

• Through appropriate scientific exchange, builds and maintains professional relationship with external stakeholders to expand Pharvaris’ research, advisory and educational partnership opportunities.
• Ensures high standard of professionalism to develop and maintain “peer-to-peer” scientific relationships with key thought leaders in healthcare, academia, payer, and government organizations per strategic territory plans and as requested by KOLs/HCPs, including the management of strategic scientific partnerships and scientific exchange.
• Provide scientific liaison support to Investigators currently involved in Pharvaris’ interventional or observational studies and investigator-sponsored research
• Provide scientific exchange and appropriate support to payer organizations.
• Serve as a liaison between HCPs and Pharvaris medical affairs.
• Facilitate 1:1 and group scientific interactions with healthcare professionals.
• Participate in KOL/HCP planning.
• Maintain KOL/HCP plans and update medical customer relationship management system in a timely, accurate and compliant manner.
• Maintain awareness of and access to internal and external information sources available to support high-quality scientific exchange, and coordinate high-quality interactions between these resources and external customers

Effective and Compliant Dissemination of Data

• Respond within defined timeline and quality standards to unsolicited inquiries from HCPs and other stakeholders received by Medical Affairs and referred to Global Medical Affairs by other Pharvaris functions, forwards reports of adverse events according to Pharvaris’ policy.
• Support development of appropriate responses to unique inquiries as required, such as the presentation of scientific evidence and medical education.
• Presents clinical and disease state information to a variety of audiences, including KOLs, Medical advisors, formulary/decision makers and other HCPs.
• Ensures appropriate scientific exchange with HCPs by fostering fair and balanced medical and scientific communications that are not misleading.
• Serves as scientific resource at key medical, scientific, and patient advocacy conferences as assigned.
• Conducts therapeutic training for Sales and Medical colleagues upon request

Contribute to Pharvaris Strategic Medical Strategy

• Communicate key medical insights from KOLs/HCPs to inform refinement of medical strategy.
• Gain customer insights, opinions and organization of advisory boards to gain invaluable feedback from external stakeholders
• Provide scientific input and participate in local medical and cross-functional initiatives.
• Provide field-based medical support to Pharvaris’ clinical research programs, registries, and facilitation of Investigator-sponsored Research process.
• Under the guidance of Medical Affairs leadership, provide scientific support for company-sponsored meetings.
• Participate on internal project teams as directed by Medical Affairs leadership
• Ensure alignment of medical activities with industry and Pharvaris Compliance and Regulatory standards, policies, and regulations.
• Develop medical affairs standard operating procedures and other policy guidance documents and provide active medical support to development of cross-functional policy resources

Requirements

• Doctorate level (MD, PharmD, PhD) preferred or master’s degree (MPH or equivalent) with at least 3 years of relevant experience clinical or therapeutic experience.
• 3- 5 years of MSL experience with primary emphasis on rare diseases and field-based scientific exchange and/or clinical trial support
• Therapeutic area and/ or hereditary angioedema expertise preferred.
• Frequent travel is required. Availability to travel 80% of the time, including weekends and holidays
• Establishes credible and long-lasting relationships and has personal impact through engaging respectfully and professionally.
• Focus on personal accountability and ownership – constantly challenging oneself to take responsibility for continuous performance improvement and operational excellence, reliable and predictable for colleagues and customers.
• Act on the needs of patients
• Able to exchange scientific ideas and information openly and effectively with key opinion leaders and with colleagues, excellent presentation skills of scientific and medical data to small and large audiences.
• Demonstrates in-depth therapeutic competency and expertise of the leading science in designated disease state; maintain knowledge base and scientific expertise on all assigned Pharvaris disease areas and products.
• Able to manage challenging conversations and handle objections.
• Focus on patient and customer needs.
• Able to work effectively in various settings: In-person and/or virtual.
• Effective listening skills
• Capable of building relationships and focused on identifying and responsibly advancing opportunities for scientific exchange within focus disease areas.
• Ability to work effectively on multi-disciplinary teams.
• Ability to partner and collaborate appropriately with R&D, Commercial, and other internal functions.
• Superior written and verbal communication skills
• Strong leadership and influencing skills.
• Has a winning attitude and demonstrates a commitment to goals and to Medical/MSL team with a positive approach to problems, even in the face of adversity.
• Highly motivated and self-directed with ability to think innovatively & strategically, skillfully plan, manage and prioritize multiple projects independently; demonstrates resilience and flexibility.
• Stay current and knowledgeable of applicable pharmaceutical guidelines and regulations, including, but not limited to, ICH, GCP, PhRMA, DOJ, OIG, R&D Code of Ethical Practices and company policies.
• Above average computer skills (MS Office, databases, etc)
• Clean and valid driver’s license

Pharvaris is committed to fair and equitable compensation practices. The base salary range for this role is $210,000-$230,000 per year. Actual compensation will depend on various factors, including but not limited to depth of experience, skill set, overall performance, and education. Pharvaris believes in providing a competitive compensation and benefits package. Base salary is just one component of our competitive total rewards strategy. In addition to compensation, this role offers the unique opportunity to help build and shape an early‑stage commercial organization, meaningful ownership through equity, annual performance incentives, and flexible paid time off. We encourage candidates who are motivated by the full opportunity and alignment with our mission to apply.