20bloc Jobs in Usa

Located in Thousand Oaks, California, 20BLOC is a small privately held development-stage biopharmaceutical company, driven by a mission to create breakthrough protein-based drugs to save lives. Our lead product is an innovative solution to provide oxygen to tissues. Check us out at

We are looking for a motivated and hands-on Head of Manufacturing to join our team.

How you will add value to 20BLOC

The Head of Manufacturing will lead our manufacturing and MSAT teams as we transition from pre-clinical manufacturing and move into our newly built cGMP production facility. This role is responsible for the management and day-to-day oversight of our manufacturing and MSAT functions and will provide strategic direction to the business as we continue to scale and plan for future production needs. The Head of Manufacturing works closely with quality, supply chain, R&D, and other cross-functional teams to ensure product quality, data integrity, and regulatory compliance.

Key Responsibilities

Manufacturing and MSAT Leadership

• Lead Production and MSAT as tightly integrated functions, owning day-to-day manufacturing execution and technical decision-making as the company transitions from pre-clinical operations into a new cGMP manufacturing facility
• Own day-to-day execution of manufacturing operations ensuring safe, compliant, and reliable batch execution
• Establish clear accountability for process ownership including yield, throughput, deviations, and continuous improvement

cGMP Facility and Scale-Up

• Lead manufacturing readiness activities for the new facility including operational readiness, staffing, training, and go-live execution
• Work hands-on with Engineering, Facilities, Quality, and 3rd parties to support equipment qualification and manufacturing area readiness
• Develop manufacturing strategies to support early and late-stage clinical as well as commercial manufacturing for future production and capacity expansion

MSAT & Process Ownership

• Oversee MSAT responsibilities including process characterization, tech transfer, and process validation
• Hold the MSAT team to a high bar for scientific and engineering excellence, ensuring process decisions are grounded in robust data and mechanistic understanding
• Drive data-driven process improvements under manufacturing and analytical data to improve robustness and consistency

People, Strategy, and Organizational Development

• Build, mentor, and develop a high-performing Manufacturing and MSAT team capable of operating in a fast-moving startup environment
• Establish and implement lightweight manufacturing organizational structures, workflows, and standard practices appropriate for a growing GMP operation
• Provide clear technical and operational input to leadership on manufacturing risks, timelines, and scale-up strategy

Education

• Bachelor’s degree in Biochemical Engineering, Chemical Engineering, Chemistry, or a closely related technical discipline required
• Advanced degree (M.S. or Ph.D.) in a related field preferred

Experience

• 8 years+ of experience in GMP manufacturing, MSAT, process engineering, or technical operations within biotech, biopharma, or related regulated manufacturing environments
• Demonstrated experience leading or directly supporting GMP manufacturing operations including hands-on involvement
• Prior experience supporting or leading startup activities in new facilities or new manufacturing suites
• Experience managing and developing small, highly technical teams, preferably in a startup environment
• Experience in early-stage or clinical manufacturing environments (pre-IND through Phase II) strongly preferred

Skills & Competencies

• Strong engineering or related technical foundation, with the ability to reason from first principles about process behavior, risk, and variability
• Hands-on GMP manufacturing expertise, including deviation investigation, root-cause analysis, and process troubleshooting on the production floor
• Data driven decision making, using experimental design and trend analysis of manufacturing data to improve robustness and consistency
• Ability to translate experimental processes into manufacturable GMP operations, balancing rigor, speed, and fit-for-stage execution
• Clear technical and organizational communicator and cross functional collaborator. Able to align operations, engineers, scientists, and leadership around sound technical decisions

Please apply at – in subject line: Head of Manufacturing

This is a full-time, on-site position located in Thousand Oaks, California, and requires working on-site Monday through Friday.All applicants must be authorized to work in the United States. We are not sponsoring employment visas.

Compensation: The salary range for this position is $130,000.00. to $180,000.00 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

20BLOC is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status, or other applicable legally protected characteristics.

We offer competitive compensation and benefits including health, dental, vision and life insurance, 401(k) and paid time off.

Located in Thousand Oaks, California, 20BLOC is a small privately held development-stage biopharmaceutical company, driven by a mission to create breakthrough protein-based drugs to save lives. Our lead product is an innovative solution to provide oxygen to tissues. Check us out at We are looking for a motivated and hands-on Quality Control (QC) Specialist to join our team.

How you will add value to 20BLOC

The Quality Control (QC) Specialist supports the day-to-day operation of the QC and analytical lab. The purpose is to ensure products meet testing requirements, and laboratory operation complies with regulatory requirements. This is an exciting opportunity to join an expanding start-up in a full-time position on site in Thousand Oaks, CA.

Key responsibilities

• Conduct assays under defined protocols to measure purity, potency, and stability using equipment and instruments supporting biotherapeutics.
• Execute compendial assays, ELISA, gel electrophoresis and chromatographic-based assays and qualification activities following protocols on in-process and final drug substance and drug product samples.
• Trouble-shoot and problem-solve with underlying knowledge of how the assays work when unexpected results appear.
• Write SOPs, analytical protocols and written reports in compliance to cGMP as needed.
• Perform the day-to-day operation of the QC lab and perform routine lab activities as need.
• Support the technology transfer of assays developed or qualified by CROs and outsourced parties.

Education

• Bachelor degree in analytical, biological, life sciences or related field.
• 3 to 5-year experience working in a laboratory with hands-on experience in analytical assays and qualification activities.

Experience

• Experience with Regulatory and GMP analytical chemistry.
• Hands-on experience with multiple protein analytical methods, both compendial and non-compendial, such as HPLC (SEC, AEX/CEX, HIC, RP, etc.) and additional product-specific methods such as ELISAs, electrophoretic methods (SDS-PAGE, icIEF), endotoxin, osmolality, pH and appearance preferred.
• Experience with LC/MS analyses, potency assay, PCR, western blot and MS-based methods a plus.

Skills & Competencies

• Working knowledge of and exposure to phase appropriate quality systems, including deviations, CAPA, change control, and document management systems.
• Excellent interpersonal, verbal and written communication skills and the ability to work in a cross functional collaborative work environment.
• Strong attention to detail and excellent organizational skills.

Please apply at – in subject line: Quality Control (QC) Specialist

This is a full-time, on-site position located in Thousand Oaks, California, and requires working on-site Monday through Friday. All applicants must be authorized to work in the United States. We are not sponsoring employment visas.

Compensation: The salary range for this position is $74,000.00. to $89,00.00 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

20BLOC is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status, or other applicable legally protected characteristics.

We offer competitive compensation and benefits including health, dental, vision and life insurance, 401(k) and paid time off.

Located in Thousand Oaks, California, 20BLOC is a small privately held development-stage biopharmaceutical company, driven by a mission to create breakthrough protein-based drugs to save lives. Our lead product is an innovative solution to provide oxygen to tissues. Check us out at

We are looking for a motivated and hands-on Process Technician to join our team.

How you will add value to 20BLOC

The Process Technician supports the production of our non-clinical stage and clinical stage product by applying their skills and knowledge of pharmaceutical product manufacturing in our unit operations to the cGMP standards. This is an exciting opportunity for a keen, hard-working individual to join a growing, expanding start-up in a full-time position on site in Thousand Oaks, CA.

Key responsibilities

• Operate various equipment such as manual or semi-automated processing equipment, TFF, chromatography, press, scales and temperature-controlled devices.
• Perform and monitor critical processes with the ability to troubleshoot and course correct equipment operation.
• Carry out standard operating procedures and protocols involved in pilot plant manufacturing including visual inspection, material handling and inventory control.
• Assist in the review of documentation for assigned functions such as batch records and equipment logs according to quality systems standards as required.
• Follow procedures with strict adherence to safety and compliance.
• Identify, recommend, and implement improvements related to routine functions.

Education

• Bachelor’s degree in engineering, biological science, or related field.
• Minimum experience should include related internships and/or projects during undergraduate studies, with prior experience in bioprocessing environments strong plus.

Experience

• Experience with production concepts and designs is strongly preferred.
• Exposure to proteins or protein chemistry is a strong plus.
• Direct fermentation experience is helpful.

Skills & Competencies

• Excellent interpersonal, verbal and written communication skills and the ability to work cross-functionally are essential in this collaborative work environment.
• Strong attention to detail and excellent organizational and time management skills are critical.

Please apply at – in subject line: Process Technician

This is a full-time, on-site position located in Thousand Oaks, California, and requires working on-site Monday through Friday. All applicants must be authorized to work in the United States. We are not sponsoring employment visas.

Compensation: The salary range for this position is $28-38 per hour. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

20BLOC is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status, or other applicable legally protected characteristics.

We offer competitive compensation and benefits including health, dental, vision and life insurance, 401(k) and paid time off.

Located in Thousand Oaks, California, 20BLOC is a small privately held development-stage biopharmaceutical company, driven by a mission to create breakthrough protein-based drugs to save lives. Our lead product is an innovative solution to provide oxygen to tissues. Check us out at

We are looking for a motivated and hands-on Senior QA Lead to join our team.

How you will add value to 20BLOC

The Senior QA Lead will lead all aspects of Quality Compliance in the organizations, including the Vendor Qualification, External & Internal Auditing, Inspection Management, and Management Review programs. Additionally, the role will lead all aspects of Quality Management Systems (QMS) including the Documentation, Training, Events, CAPA, and Change Control programs, to ensure compliance with applicable GxP and regulatory requirements.

The Senior QA Lead serves as the Quality authority within the organization, providing strategic direction while remaining hands-on in daily quality operations, and works closely with Manufacturing, Analytical Development, Regulatory Affairs, Supply Chain, Facilities, and Clinical to support business objectives and ensure product quality and patient safety.

Key Responsibilities

• Serve as the Quality lead and subject matter expert for all GxP-related activities, including GMP and GCP
• Establish, maintain, and continuously improve the Quality Management System (QMS)
• Ensure compliance with applicable regulations (e.g., FDA, EMA, ICH, local health authorities)
• Act as the company’s authorized quality representative for regulatory inspections and audits
• Lead and manage quality processes including:
• Quality Events, including Deviations, CAPAs, complaints, change control, and risk management
• Document control and record management
• Training and qualification programs
• Supplier qualification and oversight
• Clinical Quality oversight
• Oversee and perform batch record review, product disposition, and release activities
• Ensure validation and qualification activities are planned and executed appropriately
• Support regulatory submissions and responses to regulatory authorities
• Lead internal audits and manage external audits (regulatory, customer, supplier)
• Partner with cross-functional teams to drive quality culture and continuous improvement
• Build, mentor, and develop quality staff as the organization grows
• Provide quality metrics, reports, and recommendations to senior management

Education

• Bachelor degree in Life Sciences or a related field
• Advanced degree (Master or PhD) preferred

Experience

• Minimum of 8–10 years of experience in pharmaceutical quality (QA/QC), including GMP environments
• Prior experience in a quality leadership role, preferably in a small or mid-sized pharmaceutical company
• Direct experience interacting with regulatory authorities during inspections

Skills & Competencies

• Strong knowledge of GMP, GxP, ICH guidelines, and pharmaceutical quality systems
• Skills & Competencies
• Strong leadership with a hands-on approach
• Excellent understanding of quality systems and regulatory compliance
• Ability to work effectively in a fast-paced, resource-limited environment
• Strong problem-solving, risk assessment, and decision-making skills
• Excellent written and verbal communication skills
• Ability to influence cross-functional teams and senior stakeholders
• High attention to detail with a strong commitment to patient safety and product quality

Please apply at – in subject line: Senior QA Lead

This is a full-time, on-site position located in Thousand Oaks, CA, and requires working on-site Monday through Friday. All applicants much be authorized to work in the United States. We are not sponsoring employment visas.

Compensation: The salary range for this position is $120,000.00. to $150,000.00 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

20BLOC is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status, or other applicable legally protected characteristics. We offer competitive compensation and benefits including health, dental, vision and life insurance, 401(k) and paid time off.