Information Technology Jobs in Natick Remote

Immediate need for a talented Scientist I. This is a 12+ Months contract opportunity with long-term potential and is located in Waltham, MA, USA(Onsite). Please review the job description below and contact me ASAP if you are interested.

Job Diva ID: 26-08545

Pay Range: $ 46-$56 /hour. Employee benefits include, but are not limited to, health insurance (medical, dental, vision), 401(k) plan, and paid sick leave (depending on work location).

Key Responsibilities:

• Develop and optimize robust viral/non-viral vector purification process using advanced knowledge of column chromatography, filtration, and other downstream purification technology
• Lead and conduct viral/non-viral vector purification process development and process analytics
• Develop and optimize robust viral/non-viral vector purification process using advanced knowledge of column chromatography, filtration, and other downstream purification technology
• Develop, conduct, maintain analytical assays such as ELISA, DLS, Octet, QPCR/ddPCR, HPLC, and CE-SDS etc. for in-process sample testing to support process development
• Provide scientific and technical expertise for in-process sample testing activities, including product quality and process impurity methodologies
• Perform troubleshooting experiments and communicate findings with appropriate working groups
• Maintain industry knowledge and keep abreast of new and relevant technologies
• Perform data analysis, contribute to technical reports, external publications, patent applications and internal/external presentations
• Lead scale-up activities to implement a manufacturing process based on DSP development knowledge
• Communicate effectively with internal and external teams, e.g. CDMOs for tech transfer activities
• Mentor and support junior staff and build a culture of support and collaboration

Key Requirements and Technology Experience:

• Key skills: - Purification experience/ Protein Purification Chromatography
• Technical experience in modern analytical techniques such as spectrophotometry, ELISA, DLS, - Late-stage purification experience such as design space mapping and process robustness studies
• PhD in Biotechnology, Biochemistry, Chemical Engineering or related discipline or master’s degree with a minimum of 4 years of relevant experience or a bachelor’s degree with a minimum of 6 years of relevant experience
• Technical experience in modern analytical techniques such as spectrophotometry, ELISA, DLS, Octet, QPCR/ddPCR, HPLC, and CE-SDS
• Significant experience, knowledge and understanding of purification technologies and operations such as:
• Filtration unit operations at various scales, including depth filtration, tangential flow filtration, etc.
• Protein purification chromatography
• Virus clearance and inactivation
• Familiarity with advanced purification technologies and process analytical technologies
• Familiarity with analytical method transfer, analytical method bridging across organizations
• Experience with process technology transfers and performing gap analyses and risk assessments
• Understanding of critical quality attributes and the principles of Quality by Design and ability to apply DOE to downstream development
• Expertise in technical report writing
• Experience in AAV and/or non-viral purification development
• Experience in writing CMC components of regulatory dossiers
• Knowledge of product comparability, target product profile and quality risk assessment activities
• Viral clearance study design and execution
• Late-stage purification experience such as design space mapping and process robustness studies
• Ability to work in Biosafety Level 2, follow safe lab procedures and maintain good laboratory practices (GLPs)
• Ability to work under minimal supervision and function within a collaborative, team-oriented environment
• Excellent organization and communication skills
• Innovative, critical and creative thinker, unafraid of proposing aggressive solutions to complex problems
• Experience with biophysical characterization
• Experience in continuous manufacturing and process analytical technology
• Experience in mentoring junior staff
• Ability to build and nurture cross-functional relationships
• Ability to communicate and represent group in diverse, multi-functional meetings

Our client is a leading Pharmaceuticals industry , and we are currently interviewing to fill this and other similar contract positions. If you are interested in this position, please apply online for immediate consideration

Pyramid Consulting, Inc. provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, colour, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state, or local laws.

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Title: Lead Software Engineer - AI Application Platform

Mode of interview 1 round in person

Location: Must be in Charlotte, NC to work Hybrid Model

Main Skill set: Python, AI and Angular

Description:

Lead Software Engineer - AI Application Platform

The Opportunity

We are seeking a Lead Software Engineer to guide the architectural development and execution of the client, a sophisticated AI-powered application generation platform. This role suits a proven technical leader with deep, hands-on expertise across the full software stack who finds enabling a team to build better software deeply satisfying.

You will shape critical systems, mentor senior and junior developers through complex technical decisions, conduct rigorous code reviews across multiple technology domains, and directly influence the platform's trajectory through strategic engineering leadership.

This is for someone who:

• Engages thoughtfully when a junior developer asks targeted architectural questions—because you see an opportunity to shape how someone thinks about systems
• Takes time to explain subtle type-safety issues in code review, understanding that feedback is a teaching moment
• Can present architecture clearly to executives and confidently explain both what we're building and why it matters
• Finds more energy in the code your team ships than in the code you write individually
• Has proven depth across the full stack and a track record of developing engineers into stronger contributors

This is not a single-language codebase. The role requires the ability to make informed decisions on TypeScript design patterns, Python FastAPI architecture, AWS security posture, and Terraform state management in context with one another.

The Platform Challenge

The client is fundamentally a Platform-as-a-Service (PaaS) for dynamic application generation. This differs from building a traditional SaaS product. Rather than building one application, you're building infrastructure that enables users to build their own applications.

What this means architecturally:

• Dynamic Content Generation at Scale: Unlike traditional development where code is fixed, AppGen generates JSON form schemas, validation rules, and UI layouts on demand. The FormBuilder component doesn't know what fields will exist until runtime. The layout engine renders user-designed screens from configuration, not hardcoded templates.
• Multi-Tenant Isolation & Data Segregation: Each user gets their own generated app, potentially deployed to their own AWS environment. The architecture must account for data isolation, namespace management, and cross-tenant security considerations.
• User-Defined Data Structures: Traditional applications are built with predetermined database schemas. AppGen works differently—form structures, field types, and validation rules emerge from user conversations with Claude. This brings engineering challenges: How do you safely execute validation logic that users define? When users modify existing forms that have thousands of submissions, how do you maintain backward compatibility? How do you version schemas?
• Content Rendering, Not Code Generation: Unlike traditional no-code platforms where users drag-and-drop to build, AppGen uses AI instead. Users chat with Claude, Claude generates a form schema, and your platform renders that schema reliably across diverse field types, validation patterns, and workflows. The system renders configurations for immediate use, rather than generating code for later deployment.

Experience that directly transfers:

• You've contributed to or led development of low-code/no-code platforms (visual builders, workflow engines, configuration-driven systems)
• You've worked on SaaS platforms with multi-tenant architecture and understand isolation strategies, rate limiting, and per-customer customization
• You've built dynamic rendering systems that handle unknown/arbitrary schemas at runtime
• You've addressed the unique challenges of treating data configurations as user-created content (form builders, report designers, automation workflows)
• You understand the difference between platform infrastructure and applications built on that infrastructure—and the architectural implications of each

Core Responsibilities

1. Technical Architecture & Systems Thinking (40%)

• Shape architectural decisions across the full stack: How should the component layer handle dynamically generated forms? What's the right approach to validate complex cross-field dependencies in the FormBuilder? What separation of concerns makes sense between the Generator Lambda and the Parent Backend?
• Guide architecture discussions: Help senior developers think through design trade-offs. Should we use NgRx or Angular signals for this feature? When does a new Lambda function become worthwhile given cold-start costs?
• Identify and address system-wide bottlenecks: Work across layers to improve performance. Explore Lambda cold-start optimization, RDS query efficiency, and DynamoDB access patterns.
• Establish patterns and guide consistency: Define coding conventions that work across Python, TypeScript, and Terraform. Help new team members understand the reasoning behind architectural choices.
• What this looks like in practice: You're able to justify architectural decisions with technical reasoning. When someone questions an approach, you can explain the trade-offs you considered. You can write code in multiple languages to validate an approach if needed.

2. Code Review & Technical Guidance (30%)

• Full-stack PR reviews: Review Python FastAPI endpoints and Angular components with equal depth, understanding how they interact.
• Deep technical review: Catch issues thoughtful code review can surface:
• RxJS Observable lifecycle and potential memory patterns in Angular
• Query efficiency and data loading patterns in SQLAlchemy
• Terraform module organization and state management implications
• Type safety and TypeScript coverage gaps
• AWS security and IAM configurations
• Educational feedback: Your code reviews help the team learn. When you identify an issue, reviewees understand not just what changed, but how to think about similar problems in the future.
• Define quality expectations: Work with the team to establish what "production-ready" means for this platform and support consistent application of those standards.
• What this requires: Experience reviewing code across teams and multiple languages. You know how to write feedback that resonates—clear, constructive, and focused on helping people improve.

3. Mentorship & Team Development (20%)

• Expand specialist capabilities: Help backend specialists learn to contribute to the forms-engine. Support frontend experts in understanding FastAPI patterns.
• Accelerate junior developers: Pair on complex problems. Explain the reasoning behind patterns like DataState. Connect architectural choices to implementation details and performance implications.
• Identify and address gaps: Recognize when someone is struggling with a technology and provide targeted support—training, pair programming, or guidance through architectural decisions.
• Create growth opportunities: Stretch the team into new areas. A backend engineer working on their first Terraform contribution. A frontend specialist implementing an AWS Lambda authorizer.
• What this requires: Genuine investment in people's growth. You've walked developers through major transitions (generalist to specialist, specialist to full-stack, or into new technology areas). You understand that team strength grows when individuals expand their capabilities.

4. Stakeholder Communication & Technical Leadership (10%)

• Explain to diverse audiences: Translate architectural choices and trade-offs for product managers, executives, and business stakeholders. Connect "optimizing DynamoDB queries" to "improving form submission latency by 30%."
• Shape technical direction: Contribute the engineering perspective on feasibility, risk, and what unlocks future capabilities.
• Support release confidence: You understand the code changes, comprehend the risks, and know what to monitor. You can stand behind releases.

Required Qualifications

Technical Skills

Frontend (Production Experience)

• 5+ years of Angular (including handling version migrations, optimizing change detection, and guiding teams through reactive patterns)
• Strong TypeScript skills with generics, discriminated unions, and strict mode
• RxJS depth: You understand hot vs. cold observables, unsubscription patterns, and can identify potential memory issues in reviews
• NgRx state management: You've designed stores at scale, optimized selectors, and evaluated architectural implications
• CSS Grid & Responsive Design: You can assess component hierarchy and layout decisions
• Material Design: You've worked within it and know when and how to extend it

Backend (Production Experience)

• 5+ years of Python (async/await, type hints, data modeling)
• FastAPI production experience: session management, dependency injection, middleware
• SQL and ORMs (SQLAlchemy): You write efficient queries and review them critically
• AWS services: Understanding of Lambda behavior, IAM least-privilege patterns, VPC networking
• REST API design: Versioning, error handling, idempotency
• Testing frameworks: pytest, testing st

*At Securian Financial the internal position title is Engineering Sr Analyst, Engineering Analyst, or Engineering Consultant. The title and salary will be determined based on experience and applied skills.*

Summary:

The Digital Standards Guide (DSG) team is responsible for the development, maintenance, and evolution of Securian's enterprise design system - delivering reusable, accessible, and brandaligned UI components used across digital experiences. Our work enables consistency, efficiency, and highquality user experiences by partnering closely with UX, design, accessibility, and product teams. We support the full lifecycle of components, from discovery and design through development, testing, accessibility validation, and documentation.

We are seeking a FrontEnd Development Engineer who is passionate about building accessible, scalable, and usercentered interfaces. In this role, you will develop and support DSG components and patterns that empower product teams across the organization. You will work closely with design, accessibility consultants, and product partners to ensure solutions meet brand standards, usability best practices, and technical excellence.

Responsibilities include but not limited to:

• Develop, test, review, and maintain frontend components and patterns using HTML, CSS/Sass, JavaScript, and ARIA to meet accessibility standards.

• Build reusable, flexible, and scalable UI components and patterns aligned to DSG guidelines and Securian's brand.

• Support the component lifecycle, including intake, development, QA, accessibility audit, iteration, and release.

• Collaboration & Partnership

• Work closely with UX designers, accessibility specialists, analytics partners, and product teams to build solutions that meet user needs.

• Participate in design reviews, provide engineering perspective, and advise teams adopting DSG components.

• Partner with product teams to identify improvements and ensure successful implementation across applications.

• Documentation & Guidance

• Contribute to technical documentation, usage guidance, best practices, and migration/support materials for developers and designers.

• Assist in maintaining and improving internal DSG resources, including documentation sites and onboarding materials.

• Continuous Improvement

• Stay up to date on modern frontend standards, accessibility guidelines, and design system best practices.

• Identify opportunities to enhance component quality, performance, scalability, and accessibility.

Qualifications:

• 2+ years of experience with frontend development using HTML, CSS/Sass, and JavaScript.

• Strong understanding of semantic markup, accessibility fundamentals, and ARIA.

• Experience building reusable, maintainable frontend components or UI patterns.

• Proficiency with version control systems (preferably Git, GitHub).

• Ability to selfmanage workload, prioritize tasks, and meet deadlines with minimal supervision.

• Clear verbal and written communication skills; strong collaboration mindset.

• Creative problemsolver with a resultsoriented approach.

Preferred Qualifications:

• Experience with design systems or component library development.

• Knowledge of WCAG 2.x guidelines and experience writing Level AAcompliant code.

• Experience with modern build tools such as npm,Webpack, Rollup, or Vite.

• Familiarity with Adobe Experience Manager (AEM).

• Experience writing automated tests (unit, visual regression, accessibility).

• Experience with CSS preprocessors or frameworks (LESS, Sass).

• Familiarity with Web Components and componentdriven architectures.

#LI-hybrid **This position will be in a hybrid working arrangement.**

Securian Financial believes in hybrid work as an integral part of our culture. Associates get the benefit of working both virtually and in our offices. If you're in a commutable distance (90 minutes), you'll join us 3 days each week in our offices to collaborate and build relationships. Our policy allows flexibility for the reality of business and personal schedules.

The estimated base pay range for this job is:

Pay may vary depending on job-related factors and individual experience, skills, knowledge, etc. More information on base pay and incentive pay (if applicable) can be discussed with a member of the Securian Financial Talent Acquisition team.

Be you. With us. At Securian Financial, we understand that attracting top talent means offering more than just a job - it means providing a rewarding and fulfilling career. As a valued member of our high-performing team, we want you to connect with your work, your relationships and your community. Enjoy our comprehensive range of benefits designed to enhance your professional growth, well-being and work-life balance, including the advantages listed here:

Paid time off:

• We want you to take time off for what matters most to you. Our PTO program provides flexibility for associates to take meaningful time away from work to relax, recharge and spend time doing what's important to them. And Securian Financial rewards associates for their service by providing additional PTO the longer you stay at Securian.

• Leave programs: Securian's flexible leave programs allow time off from work for parental leave, caregiver leave for family members, bereavement and military leave.

• Holidays: Securian provides nine company paid holidays.

Company-funded pension plan and a 401(k) retirement plan: Share in the success of our company. Securian's 401(k) company contribution is tied to our performance up to 10 percent of eligible earnings, with a target of 5 percent. The amount is based on company results compared to goals related to earnings, sales and service.

Health insurance: From the first day of employment, associates and their eligible family members - including spouses, domestic partners and children - are eligible for medical, dental and vision coverage.

Volunteer time: We know the importance of community. Through company-sponsored events, volunteer paid time off, a dollar-for-dollar matching gift program and more, we encourage you to support organizations important to you.

Associate Resource Groups: Build connections, be yourself and develop meaningful relationships at work through associate-led ARGs. Dedicated groups focus on a variety of interests and affinities, including:

• Mental Wellness and Disability

• Pride at Securian Financial

• Securian Young Professionals Network

• Securian Multicultural Network

• Securian Women and Allies Network

• Servicemember Associate Resource Group

For more information regarding Securian's benefits, please review our Benefits page.

This information is not intended to explain all the provisions of coverage available under these plans. In all cases, the plan document dictates coverage and provisions.

Securian Financial Group, Inc. does not discriminate based on race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, marital or familial status, pregnancy, disability, genetic information, political affiliation, veteran status, status in regard to public assistance or any other protected status. If you are a job seeker with a disability and require an accommodation to apply for one of our jobs, please contact us by email at , by telephone (voice), or 711 (Relay/TTY).

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