Jobs in Millbury Worcester County Ma Remote

Scientist II

Location: Worcester, MA

Work Arrangement: 100% onsite

Contract Duration: 12 months

Overview

We are seeking a highly motivated and talented Scientist II to join our In Vivo Antibody Discovery and Molecular Core team in Worcester, MA. This is a newly created role driven by increased workload, supporting a team of six scientists.

This R&D-focused position centers on high-throughput next generation sequencing (NGS), primarily working with human cells. The role involves upstream processing, including working with primary cells (p cells), DNA extraction, sequencing preparation, and data analysis, with results shared with downstream scientists.

Key Responsibilities

Experimental Design & Execution

• Independently design, execute, and interpret experiments utilizing microfluidics to amplify heavy and light chain genes and generate DNA libraries for deep sequencing of single B cells captured in droplet emulsions
• Understand project objectives and adapt experimental plans as needed while meeting timelines

Molecular Techniques

• Perform RNA isolation and DNA purification
• Amplify antibody heavy- and light-chain variable regions from single cells or lysates
• Prepare and submit DNA libraries for next generation sequencing (MiSeq/MiSeq i100)

Bioinformatics & Data Analysis

• Conduct sequencing data analysis of cells
• Perform in silico antibody genetic analysis and data visualization using standard and custom bioinformatics tools
• Utilize coding/data analysis at a basic to intermediate level (preferred)

Collaboration

• Present and discuss experimental findings with cross-functional teams
• Support multiple programs across the in vivo antibody discovery portfolio
• Work both independently and collaboratively while managing multiple projects

Qualifications

• 3–5 years of experience
• Hands-on experience with DNA sequencing (Illumina) – required
• Microfluidic experience – required
• Experience working with next generation sequencing (NGS)
• Molecular biology expertise
• DNA/RNA purification experience
• Primary cell (p cell) experience
• Data analysis background – preferred
• Basic to intermediate coding/data experience – preferred

Education

• Bachelor’s or Master’s degree required
• PhD is overqualified (OQ)

Required Skills & Experience

• Master’s degree in biology, immunology, cell/molecular biology, or related discipline with experience in single B cell sequencing research and 2+ years of relevant experience (MS)
• Demonstrated hands-on expertise in droplet microfluidics of single B cells and next generation sequencing of IgG variable heavy and light chains
• Familiarity with next generation sequencing platforms (Illumina MiSeq and MiSeq i100) and B cell genetic data analysis software/databases (FLASH, IgBlast, Usearch, IMGT)
• Experience in reverse transcription, RNA/DNA isolation and purification, overlap extension PCR, primer design, cDNA library generation, and gel electrophoresis
• Protein and cell detection methods experience (ELISA and/or FACS) – preferred

Additional Details

• Reason for Need: New role due to increased workload
• Team Size: 6

100% ONSITE

Pay: $48-$52/hr

REQUIRED:

• Minimum: Master’s degree + 2‑5 years relevant experience
• Bachelor’s acceptable with 5 years strong hands‑on background
• Background in microbiology, immunology, cell/molecular biology, or biotech
• Hands‑on experience with NGS (Illumina MiSeq/iSeq) – must‑have
• Microfluidics: emulsion, droplet generation, custom or commercial systems
• B‑cell purification and handling
• Molecular biology: polymerase reactions, RNA/DNA purification, indexing
• Basic data analysis; familiarity with commercial sequencing software
• Scripting in Python or R for data processing (plus)
• Bioinformatics tools (IMGT, IgBLAST)
• Protein detection methods (ELISA, similar assays)
• Experience with other NGS platforms (Thermo Fisher, PacBio, ONT) – nice to have

Job Description:

B-Cell Sequencing is the focus of this group - downstream (Extracting antibodies from individual B cells and sequencing them to find new drug candidates)

The successful candidate will support the development of new paired antibody sequencing technologies from single B cells using droplet microfluidics. Responsibilities include experimental planning and execution, comprehensive B cells sequencing analysis and presentation, and detailed documentation to support multiple programs across our in vivo antibody discovery portfolio.

Responsibilities

- Experimental Design & Execution: Independently design, execute and interpret experiments utilizing microfluidics to amplify heavy and light chain genes and generate DNA libraries for deep sequencing of single B cells captured in droplet emulsions.

- Understand the broad objectives of the project as well as their role in achieving those objectives, and modify the experimental plan when required. Set and meet experimental timelines.

- Molecular Techniques: Demonstrate a high level of proficiency in conducting RNA isolation, and DNA purification, and related methods to amplify antibody heavy- and light-chain variable regions from single cells or lysates and submit DNA libraries for next generation sequencing (MiSeq/MiSeq i100).

- Bioinformatics Data Analysis: Perform comprehensive in silico antibody genetic analysis and data visualization using standard and custom antibody bioinformatic tools – to guide program decisions and deliver biotherapeutic candidates.

- Cross-Functional Collaboration: Collaborate with multidisciplinary teams to present/discuss experimental findings to ensure alignment with overall biotherapeutic development goals.

- Ability to work independently and as part of a team, managing multiple projects simultaneously.

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